Hydroxyzine hydrochlorideProduct ingredient for Hydroxyzine
- Name
- Hydroxyzine hydrochloride
- Drug Entry
- Hydroxyzine
Hydroxyzine is a first-generation histamine H1-receptor antagonist of the dephenylmethane and piperazine classes that exhibits sedative, anxiolytic, and antiemetic properties.2,12 It was first developed in 1955,10 and has since remained a relatively common treatment for allergic conditions such as pruritus, urticaria, dermatoses, and histamine-mediated pruritus.18 The active metabolite of hydroxyzine, cetirizine, is also available as an active ingredient in allergic medications, and is responsible for much of its hydroxyzine's antihistaminic effect.13 Hydroxyzine is also used for generalized anxiety disorder, tension caused by psychoneurosis, and other conditions with manifestations of anxiety.18
- Accession Number
- DBSALT000343
- Structure
- Synonyms
- Hydroxyzine dihydrochloride / Hydroxyzine HCl
- UNII
- 76755771U3
- CAS Number
- 2192-20-3
- Weight
- Average: 447.826
Monoisotopic: 446.129461303 - Chemical Formula
- C21H29Cl3N2O2
- InChI Key
- ANOMHKZSQFYSBR-UHFFFAOYSA-N
- InChI
- InChI=1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H
- IUPAC Name
- 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethan-1-ol dihydrochloride
- SMILES
- Cl.Cl.OCCOCCN1CCN(CC1)C(C1=CC=CC=C1)C1=CC=C(Cl)C=C1
- External Links
- KEGG Drug
- D00672
- PubChem Compound
- 91513
- ChemSpider
- 82634
- ChEBI
- 5819
- ChEMBL
- CHEMBL3186993
- Wikipedia
- Hydroxyzine
- Predicted Properties
Property Value Source Water Solubility 0.0914 mg/mL ALOGPS logP 3.43 ALOGPS logP 3.41 Chemaxon logS -3.6 ALOGPS pKa (Strongest Acidic) 15.12 Chemaxon pKa (Strongest Basic) 7.45 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 35.94 Å2 Chemaxon Rotatable Bond Count 8 Chemaxon Refractivity 107.07 m3·mol-1 Chemaxon Polarizability 41.71 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon