Ranolazine hydrochlorideProduct ingredient for Ranolazine
- Name
- Ranolazine hydrochloride
- Drug Entry
- Ranolazine
Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities.11 Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms.17 With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.15
- Accession Number
- DBSALT000388
- Structure
- Synonyms
- Ranolazine dihydrochloride / Ranolazine HCl
- UNII
- F71253DJUN
- CAS Number
- 95635-56-6
- Weight
- Average: 500.458
Monoisotopic: 499.200462037 - Chemical Formula
- C24H35Cl2N3O4
- InChI Key
- RJNSNFZXAZXOFX-UHFFFAOYSA-N
- InChI
- InChI=1S/C24H33N3O4.2ClH/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3;;/h4-10,20,28H,11-17H2,1-3H3,(H,25,29);2*1H
- IUPAC Name
- N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}ethanimidic acid dihydrochloride
- SMILES
- Cl.Cl.COC1=CC=CC=C1OCC(O)CN1CCN(CC(O)=NC2=C(C)C=CC=C2C)CC1
- External Links
- PubChem Compound
- 71279
- ChemSpider
- 64403
- ChEMBL
- CHEMBL1526084
- Predicted Properties
Property Value Source Water Solubility 0.118 mg/mL ALOGPS logP 2.27 ALOGPS logP 1.34 Chemaxon logS -3.6 ALOGPS pKa (Strongest Acidic) 4.7 Chemaxon pKa (Strongest Basic) 7.21 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 77.76 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 124.22 m3·mol-1 Chemaxon Polarizability 47.18 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon