Ranolazine hydrochlorideProduct ingredient for Ranolazine

Name
Ranolazine hydrochloride
Drug Entry
Ranolazine

Chronic angina is a common cardiovascular condition affecting millions worldwide and causes significant disability while interfering with daily activities.11 Ranolazine is a well-tolerated piperazine derivative used for the management of this condition, offering relief from uncomfortable and debilitating symptoms.17 With a mechanism of action different from drugs used to treat the same condition, ranolazine is a promising anti-anginal therapy. It was originally approved by the FDA in 2006.15

Accession Number
DBSALT000388
Structure
Synonyms
Ranolazine dihydrochloride / Ranolazine HCl
UNII
F71253DJUN
CAS Number
95635-56-6
Weight
Average: 500.458
Monoisotopic: 499.200462037
Chemical Formula
C24H35Cl2N3O4
InChI Key
RJNSNFZXAZXOFX-UHFFFAOYSA-N
InChI
InChI=1S/C24H33N3O4.2ClH/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3;;/h4-10,20,28H,11-17H2,1-3H3,(H,25,29);2*1H
IUPAC Name
N-(2,6-dimethylphenyl)-2-{4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]piperazin-1-yl}ethanimidic acid dihydrochloride
SMILES
Cl.Cl.COC1=CC=CC=C1OCC(O)CN1CCN(CC(O)=NC2=C(C)C=CC=C2C)CC1
PubChem Compound
71279
ChemSpider
64403
ChEMBL
CHEMBL1526084
Predicted Properties
PropertyValueSource
Water Solubility0.118 mg/mLALOGPS
logP2.27ALOGPS
logP1.34Chemaxon
logS-3.6ALOGPS
pKa (Strongest Acidic)4.7Chemaxon
pKa (Strongest Basic)7.21Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count7Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area77.76 Å2Chemaxon
Rotatable Bond Count9Chemaxon
Refractivity124.22 m3·mol-1Chemaxon
Polarizability47.18 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveNoChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon