Nefazodone hydrochlorideProduct ingredient for Nefazodone
- Name
- Nefazodone hydrochloride
- Drug Entry
- Nefazodone
Nefazodone hydrochloride (trade name Serzone) is an antidepressant drug marketed by Bristol-Myers Squibb. Its sale was discontinued in 2003 in some countries, due to the small possibility of hepatic (liver) injury. Drug-induced hepatic injuries were associated with an risk of elevated need for a liver transplant, or even death, with the incidence of severe liver damage was shown to be approximately 1 in 250,000 to 300,000 patient-years. On May 20, 2004, Bristol-Myers Squibb discontinued the sale of Serzone in the United States.
- Accession Number
- DBSALT000406
- Structure
Structure for Nefazodone hydrochloride (DBSALT000406)
- Synonyms
- Nefazodone HCl
- UNII
- 27X63J94GR
- CAS Number
- 82752-99-6
- Weight
- Average: 506.468
Monoisotopic: 505.201130739 - Chemical Formula
- C25H33Cl2N5O2
- InChI Key
- DYCKFEBIOUQECE-UHFFFAOYSA-N
- InChI
- InChI=1S/C25H32ClN5O2.ClH/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22;/h3-6,8-11,20H,2,7,12-19H2,1H3;1H
- IUPAC Name
- 1-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-3-ethyl-4-(2-phenoxyethyl)-4,5-dihydro-1H-1,2,4-triazol-5-one hydrochloride
- SMILES
- Cl.CCC1=NN(CCCN2CCN(CC2)C2=CC=CC(Cl)=C2)C(=O)N1CCOC1=CC=CC=C1
- External Links
- PubChem Compound
- 54911
- ChemSpider
- 49584
- ChEBI
- 7495
- ChEMBL
- CHEMBL1200492
- Wikipedia
- Nefazodone
- Predicted Properties
Property Value Source Water Solubility 0.0698 mg/mL ALOGPS logP 3.71 ALOGPS logP 4.65 Chemaxon logS -3.8 ALOGPS pKa (Strongest Basic) 7.09 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 51.62 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 132.38 m3·mol-1 Chemaxon Polarizability 51.96 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon