Tiludronate DisodiumProduct ingredient for Tiludronic acid

Tiludronate, or (4-chlorophenyl)thio-methylene-1,1-bisphosphonate, is a first generation bisphosphonate similar to etidronic acid and clodronic acid.^1,7 These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification.¹ Tiludronic acid was first described in the literature in 1988 as a potential treatment for Paget's disease of bone.⁵

Tiludronic acid was granted FDA approval on 7 March 1997.⁸