Clonidine hydrochlorideProduct ingredient for Clonidine

Name
Clonidine hydrochloride
Drug Entry
Clonidine

Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.2 This activity is useful for the treatment of hypertension, severe pain, and ADHD.8,9,10,11

Clonidine was granted FDA approval on 3 September 1974.8

Accession Number
DBSALT000538
Structure
Synonyms
Clonidine HCl
UNII
W76I6XXF06
CAS Number
4205-91-8
Weight
Average: 266.555
Monoisotopic: 264.994030456
Chemical Formula
C9H10Cl3N3
InChI Key
ZNIFSRGNXRYGHF-UHFFFAOYSA-N
InChI
InChI=1S/C9H9Cl2N3.ClH/c10-6-2-1-3-7(11)8(6)14-9-12-4-5-13-9;/h1-3H,4-5H2,(H2,12,13,14);1H
IUPAC Name
N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride
SMILES
Cl.ClC1=CC=CC(Cl)=C1NC1=NCCN1
PubChem Compound
20179
ChemSpider
19006
BindingDB
50020341
ChEBI
3758
ChEMBL
CHEMBL1705
Wikipedia
Clonidine
Predicted Properties
PropertyValueSource
Water Solubility0.48 mg/mLALOGPS
logP2.55ALOGPS
logP2.49Chemaxon
logS-2.7ALOGPS
pKa (Strongest Basic)8.16Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area36.42 Å2Chemaxon
Rotatable Bond Count1Chemaxon
Refractivity59.09 m3·mol-1Chemaxon
Polarizability21.7 Å3Chemaxon
Number of Rings2Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleNoChemaxon