Tizanidine hydrochlorideProduct ingredient for Tizanidine

Name
Tizanidine hydrochloride
Drug Entry
Tizanidine

Tizanidine is a fast-acting drug used for the management of muscle spasm, which may result from the effects of multiple sclerosis, stroke, an acquired brain injury, or a spinal cord injury 9. It may also be caused by musculoskeletal injury 5. Regardless of the cause, muscle spasticity can be an extremely painful and debilitating condition.

Initially approved by the FDA in 1996, tizanidine is an Alpha-2 adrenergic receptor agonist reducing spasticity by the presynaptic inhibition of excitatory neurotransmitters that cause firing of neurons promoting muscle spasm Label.

Accession Number
DBSALT000550
Structure
Thumb
Synonyms
Tizanidine HCl
UNII
B53E3NMY5C
CAS Number
64461-82-1
Weight
Average: 290.172
Monoisotopic: 288.995571417
Chemical Formula
C9H9Cl2N5S
InChI Key
ZWUKMNZJRDGCTQ-UHFFFAOYSA-N
InChI
InChI=1S/C9H8ClN5S.ClH/c10-5-1-2-6-8(15-16-14-6)7(5)13-9-11-3-4-12-9;/h1-2H,3-4H2,(H2,11,12,13);1H
IUPAC Name
5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine hydrochloride
SMILES
Cl.ClC1=C(NC2=NCCN2)C2=NSN=C2C=C1
PubChem Compound
114869
ChemSpider
102826
ChEBI
9609
ChEMBL
CHEMBL1200329
Wikipedia
Tizanidine
Predicted Properties
PropertyValueSource
Water Solubility0.133 mg/mLALOGPS
logP1.6ALOGPS
logP2.02ChemAxon
logS-3.3ALOGPS
pKa (Strongest Basic)7.49ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area62.2 Å2ChemAxon
Rotatable Bond Count1ChemAxon
Refractivity64.77 m3·mol-1ChemAxon
Polarizability23.99 Å3ChemAxon
Number of Rings3ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon