Loperamide hydrochlorideProduct ingredient for Loperamide

Loperamide is an anti-diarrheal agent that is available as an over-the-counter product for treating diarrhea.⁷ The drug was first synthesized in 1969 and used medically in 1976.¹ It is a highly lipophilic synthetic phenylpiperidine opioid that works by binding to mu-opioid receptors on intestinal muscles to decrease intestinal motility and electrolyte loss.¹ Loperamide has a chemical structure that is similar to diphenoxylate and haloperidol;² however, loperamide works on mu (μ)-opioid receptors to mediate its pharmacological actions.¹