Procarbazine hydrochlorideProduct ingredient for Procarbazine

Name
Procarbazine hydrochloride
Drug Entry
Procarbazine

An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.

Accession Number
DBSALT000731
Structure
Synonyms
Procarbazine HCl
UNII
XH0NPH5ZX8
CAS Number
366-70-1
Weight
Average: 294.221
Monoisotopic: 293.106167723
Chemical Formula
C12H21Cl2N3O
InChI Key
OCSSHHHAHMCFDV-UHFFFAOYSA-N
InChI
InChI=1S/C12H19N3O.2ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);2*1H
IUPAC Name
4-[(2-methylhydrazin-1-yl)methyl]-N-(propan-2-yl)benzamide dihydrochloride
SMILES
Cl.Cl.CNNCC1=CC=C(C=C1)C(=O)NC(C)C
PubChem Compound
23616826
ChemSpider
19953253
Wikipedia
Procarbazine
Predicted Properties
PropertyValueSource
Water Solubility0.228 mg/mLALOGPS
logP0.53ALOGPS
logP0.99Chemaxon
logS-3ALOGPS
pKa (Strongest Acidic)15.03Chemaxon
pKa (Strongest Basic)5.56Chemaxon
Physiological Charge0Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count3Chemaxon
Polar Surface Area53.16 Å2Chemaxon
Rotatable Bond Count5Chemaxon
Refractivity86.98 m3·mol-1Chemaxon
Polarizability25.81 Å3Chemaxon
Number of Rings1Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon