Colesevelam hydrochlorideProduct ingredient for Colesevelam
- Name
- Colesevelam hydrochloride
- Drug Entry
- Colesevelam
Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in the body. Removing these bile acids helps to lower blood cholesterol.
- Accession Number
- DBSALT000790
- Structure
- Synonyms
- Colesevelam HCl
- UNII
- P4SG24WI5Q
- CAS Number
- 182815-44-7
- Weight
- Average: 618.249
Monoisotopic: 616.438045907 - Chemical Formula
- C31H67Cl3N4O
- InChI Key
- VTAKZNRDSPNOAU-UHFFFAOYSA-M
- InChI
- InChI=1S/C13H27N.C12H27N2.C3H5ClO.C3H7N.2ClH/c1-3-5-6-7-8-9-10-11-13-14-12-4-2;1-5-10-13-11-8-6-7-9-12-14(2,3)4;4-1-3-2-5-3;1-2-3-4;;/h4,14H,2-3,5-13H2,1H3;5,13H,1,6-12H2,2-4H3;3H,1-2H2;2H,1,3-4H2;2*1H/q;+1;;;;/p-1
- IUPAC Name
- 2-(chloromethyl)oxirane decyl(prop-2-en-1-yl)amine prop-2-en-1-amine trimethyl({6-[(prop-2-en-1-yl)amino]hexyl})azanium hydrochloride chloride
- SMILES
- Cl.[Cl-].NCC=C.ClCC1CO1.CCCCCCCCCCNCC=C.C[N+](C)(C)CCCCCCNCC=C
- External Links
- PubChem Compound
- 160051
- ChemSpider
- 140701
- PharmGKB
- PA449095
- Wikipedia
- Colesevelam
- Predicted Properties
Property Value Source Water Solubility 0.00175 mg/mL ALOGPS logP 4.85 ALOGPS logP 4.53 Chemaxon logS -5 ALOGPS pKa (Strongest Basic) 9.93 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 12.03 Å2 Chemaxon Rotatable Bond Count 22 Chemaxon Refractivity 65.34 m3·mol-1 Chemaxon Polarizability 27.32 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon