Bicifadine hydrochlorideProduct ingredient for Bicifadine
- Name
- Bicifadine hydrochloride
- Drug Entry
- Bicifadine
Bicifadine (DOV-220075) is a nonopioid analgesic. It is an inhibitor of both the norepinephrine and serotonin transporters and an NMDA antagonist with a non-narcotic profile. Bicifadine was shown to have potent analgesic activity in vivo and was chosen for further development for the treatment of pain.
- Accession Number
- DBSALT000817
- Structure
Structure for Bicifadine hydrochloride (DBSALT000817)
- Synonyms
- Bicifadine HCl
- UNII
- OE6G20P68T
- CAS Number
- 66504-75-4
- Weight
- Average: 209.715
Monoisotopic: 209.097127224 - Chemical Formula
- C12H16ClN
- InChI Key
- OTZOPAFTLUOBOM-UHFFFAOYSA-N
- InChI
- InChI=1S/C12H15N.ClH/c1-9-2-4-10(5-3-9)12-6-11(12)7-13-8-12;/h2-5,11,13H,6-8H2,1H3;1H
- IUPAC Name
- 1-(4-methylphenyl)-3-azabicyclo[3.1.0]hexane hydrochloride
- SMILES
- Cl.CC1=CC=C(C=C1)C12CC1CNC2
- External Links
- PubChem Compound
- 47952
- ChemSpider
- 43617
- ChEBI
- 647888
- ChEMBL
- CHEMBL544862
- Predicted Properties
Property Value Source Water Solubility 0.172 mg/mL ALOGPS logP 1.93 ALOGPS logP 2.06 Chemaxon logS -3 ALOGPS pKa (Strongest Basic) 10.6 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 12.03 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 54.31 m3·mol-1 Chemaxon Polarizability 20.6 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon