Alizapride hydrochlorideProduct ingredient for Alizapride

Name
Alizapride hydrochloride
Drug Entry
Alizapride

Alizapride is a dopamine antagonist that is capable of demonstrating both prokinetic and antiemetic effects. This kind of pharmacological activity makes it effective for use in the treatment of various kinds of nausea and vomiting, including that which may occur postoperatively.

Accession Number
DBSALT000918
Structure
Synonyms
Alizapride HCl
UNII
41BT72BOQ7
CAS Number
59338-87-3
Weight
Average: 351.84
Monoisotopic: 351.1462027
Chemical Formula
C16H22ClN5O2
InChI Key
BRECEDGYMYXGNF-UHFFFAOYSA-N
InChI
InChI=1S/C16H21N5O2.ClH/c1-3-6-21-7-4-5-11(21)10-17-16(22)12-8-13-14(19-20-18-13)9-15(12)23-2;/h3,8-9,11H,1,4-7,10H2,2H3,(H,17,22)(H,18,19,20);1H
IUPAC Name
6-methoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]methyl}-1H-1,2,3-benzotriazole-5-carboxamide hydrochloride
SMILES
Cl.COC1=C(C=C2N=NNC2=C1)C(=O)NCC1CCCN1CC=C
PubChem Compound
6410734
ChemSpider
4918604
ChEMBL
CHEMBL1896987
Predicted Properties
PropertyValueSource
Water Solubility0.46 mg/mLALOGPS
logP1.1ALOGPS
logP1.04Chemaxon
logS-2.8ALOGPS
pKa (Strongest Acidic)8.41Chemaxon
pKa (Strongest Basic)7.69Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count5Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area83.14 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity88.89 m3·mol-1Chemaxon
Polarizability33.54 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon