Alizapride hydrochlorideProduct ingredient for Alizapride
- Name
- Alizapride hydrochloride
- Drug Entry
- Alizapride
Alizapride is a dopamine antagonist that is capable of demonstrating both prokinetic and antiemetic effects. This kind of pharmacological activity makes it effective for use in the treatment of various kinds of nausea and vomiting, including that which may occur postoperatively.
- Accession Number
- DBSALT000918
- Structure
- Synonyms
- Alizapride HCl
- UNII
- 41BT72BOQ7
- CAS Number
- 59338-87-3
- Weight
- Average: 351.84
Monoisotopic: 351.1462027 - Chemical Formula
- C16H22ClN5O2
- InChI Key
- BRECEDGYMYXGNF-UHFFFAOYSA-N
- InChI
- InChI=1S/C16H21N5O2.ClH/c1-3-6-21-7-4-5-11(21)10-17-16(22)12-8-13-14(19-20-18-13)9-15(12)23-2;/h3,8-9,11H,1,4-7,10H2,2H3,(H,17,22)(H,18,19,20);1H
- IUPAC Name
- 6-methoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]methyl}-1H-1,2,3-benzotriazole-5-carboxamide hydrochloride
- SMILES
- Cl.COC1=C(C=C2N=NNC2=C1)C(=O)NCC1CCCN1CC=C
- External Links
- PubChem Compound
- 6410734
- ChemSpider
- 4918604
- ChEMBL
- CHEMBL1896987
- Predicted Properties
Property Value Source Water Solubility 0.46 mg/mL ALOGPS logP 1.1 ALOGPS logP 1.04 Chemaxon logS -2.8 ALOGPS pKa (Strongest Acidic) 8.41 Chemaxon pKa (Strongest Basic) 7.69 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 83.14 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 88.89 m3·mol-1 Chemaxon Polarizability 33.54 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon