Chlorpheniramine maleateProduct ingredient for Chlorpheniramine
- Name
- Chlorpheniramine maleate
- Drug Entry
- Chlorpheniramine
A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine.
- Accession Number
- DBSALT000987
- Structure
Structure for Chlorpheniramine maleate (DBSALT000987)
- Synonyms
- Chlorphenamine maleate / Chlorprophenpyridamine maleate
- UNII
- V1Q0O9OJ9Z
- CAS Number
- 113-92-8
- Weight
- Average: 390.86
Monoisotopic: 390.1346349 - Chemical Formula
- C20H23ClN2O4
- InChI Key
- DBAKFASWICGISY-BTJKTKAUSA-N
- InChI
- InChI=1S/C16H19ClN2.C4H4O4/c1-19(2)12-10-15(16-5-3-4-11-18-16)13-6-8-14(17)9-7-13;5-3(6)1-2-4(7)8/h3-9,11,15H,10,12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
- IUPAC Name
- (2Z)-but-2-enedioic acid; [3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl]dimethylamine
- SMILES
- OC(=O)\C=C/C(O)=O.CN(C)CCC(C1=CC=C(Cl)C=C1)C1=CC=CC=N1
- External Links
- KEGG Compound
- C07780
- ChemSpider
- 4444525
- ChEBI
- 3645
- ChEMBL
- CHEMBL1659
- Wikipedia
- Chlorphenamine
- Predicted Properties
Property Value Source Water Solubility 0.0519 mg/mL ALOGPS logP 3.74 ALOGPS logP 3.58 Chemaxon logS -3.7 ALOGPS pKa (Strongest Basic) 9.47 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 16.13 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 80.85 m3·mol-1 Chemaxon Polarizability 30.83 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon