Aztreonam lysineProduct ingredient for Aztreonam
- Name
- Aztreonam lysine
- Drug Entry
- Aztreonam
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.
- Accession Number
- DBSALT001061
- Structure
- Synonyms
- Not Available
- UNII
- XNM7LT65NP
- CAS Number
- 827611-49-4
- Weight
- Average: 581.62
Monoisotopic: 581.157382574 - Chemical Formula
- C19H31N7O10S2
- InChI Key
- KPPBAEVZLDHCOK-JHBYREIPSA-N
- InChI
- InChI=1S/C13H17N5O8S2.C6H14N2O2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22;7-4-2-1-3-5(8)6(9)10/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25);5H,1-4,7-8H2,(H,9,10)/b17-8-;/t5-,7-;5-/m00/s1
- IUPAC Name
- (2S)-2,6-diaminohexanoic acid; 2-{[(Z)-[(2-amino-1,3-thiazol-4-yl)({[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]carbamoyl})methylidene]amino]oxy}-2-methylpropanoic acid
- SMILES
- NCCCC[C@H](N)C(O)=O.C[C@H]1[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\C2=CSC(N)=N2)C(=O)N1S(O)(=O)=O
- External Links
- ChemSpider
- 9379087
- ChEMBL
- CHEMBL3833340
- Wikipedia
- Aztreonam
- Predicted Properties
Property Value Source Water Solubility 0.201 mg/mL ALOGPS logP 0.01 ALOGPS logP -1.9 Chemaxon logS -3.3 ALOGPS pKa (Strongest Acidic) -1.9 Chemaxon pKa (Strongest Basic) 4.14 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 11 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 201.58 Å2 Chemaxon Rotatable Bond Count 11 Chemaxon Refractivity 92.99 m3·mol-1 Chemaxon Polarizability 39.56 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon