Benzydamine hydrochlorideProduct ingredient for Benzydamine
- Name
- Benzydamine hydrochloride
- Drug Entry
- Benzydamine
Benzydamine (also known as Tantum Verde or Difflam), available as the hydrochloride salt, is a locally-acting nonsteroidal anti-inflammatory drug (NSAID) with local anaesthetic and analgesic properties. It is used topically for pain relief and anti-inflammatory treatment of the mouth, throat, or muscoskeletal system.
Although the indazole analogue benzydamine is a non-steroidal anti-inflammatory drug (NSAID), it has various physicochemical properties and pharmacologic activities that are different from those of traditional aspirin-like NSAIDs but facilitate benzydamine's mechanism of action as an effective locally-acting NSAID with local anaesthetic and analgesic properties. Moreover, unlike aspirin-like NSAIDs which are acids or metabolised to acids, benzydamine is in fact a weak base.
- Accession Number
- DBSALT001124
- Structure
Structure for Benzydamine hydrochloride (DBSALT001124)
- Synonyms
- Benzydamine HCl
- UNII
- K2GI407R4Q
- CAS Number
- 132-69-4
- Weight
- Average: 345.87
Monoisotopic: 345.1607901 - Chemical Formula
- C19H24ClN3O
- InChI Key
- HNNIWKQLJSNAEQ-UHFFFAOYSA-N
- InChI
- InChI=1S/C19H23N3O.ClH/c1-21(2)13-8-14-23-19-17-11-6-7-12-18(17)22(20-19)15-16-9-4-3-5-10-16;/h3-7,9-12H,8,13-15H2,1-2H3;1H
- IUPAC Name
- {3-[(1-benzyl-1H-indazol-3-yl)oxy]propyl}dimethylamine hydrochloride
- SMILES
- Cl.CN(C)CCCOC1=NN(CC2=CC=CC=C2)C2=CC=CC=C12
- External Links
- ChemSpider
- 58917
- ChEBI
- 31266
- ChEMBL
- CHEMBL1528134
- Wikipedia
- Benzydamine
- Predicted Properties
Property Value Source Water Solubility 0.0491 mg/mL ALOGPS logP 3.78 ALOGPS logP 3.66 Chemaxon logS -3.8 ALOGPS pKa (Strongest Basic) 9.26 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 30.29 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 105.56 m3·mol-1 Chemaxon Polarizability 35.54 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon