Hexaminolevulinate hydrochlorideProduct ingredient for Hexaminolevulinate
- Name
- Hexaminolevulinate hydrochloride
- Drug Entry
- Hexaminolevulinate
Hexaminolevulinate is an optical imaging drug. In solution form it is instilled intravesically for use with photodynamic blue light cystoscopy as an adjunct to white light cystoscopy. On May 28, 2010, the U.S. Food and Drug Administration (FDA) granted approval for hexaminolevulinate hydrochloride (Cysview for Intravesical Solution, Photocure ASA), as an optical imaging agent for use in combination with the Karl Storz Photodynamic Diagnostic D-Light C (PDD) System for cystoscopic detection of non-muscle invasive papillary cancer of the bladder for patients suspected or known to have lesion(s) on the basis of a prior cystoscopy. Hexaminolevulinate is manufactured under the brand Cysview® by Photocure ASA. In Europe, Hexaminolevulinate is marketed under the brand Hexvix®.
- Accession Number
- DBSALT001174
- Structure
Structure for Hexaminolevulinate hydrochloride (DBSALT001174)
- Synonyms
- Hexaminolevulinate HCl
- UNII
- D4F329SL1O
- CAS Number
- 140898-91-5
- Weight
- Average: 251.75
Monoisotopic: 251.1288213 - Chemical Formula
- C11H22ClNO3
- InChI Key
- LZYXPFZBAZTOCH-UHFFFAOYSA-N
- InChI
- InChI=1S/C11H21NO3.ClH/c1-2-3-4-5-8-15-11(14)7-6-10(13)9-12;/h2-9,12H2,1H3;1H
- IUPAC Name
- hexyl 5-amino-4-oxopentanoate hydrochloride
- SMILES
- Cl.CCCCCCOC(=O)CCC(=O)CN
- External Links
- ChemSpider
- 4938271
- ChEMBL
- CHEMBL1201785
- Wikipedia
- Hexaminolevulinate
- Predicted Properties
Property Value Source Water Solubility 0.511 mg/mL ALOGPS logP 1.55 ALOGPS logP 1.37 Chemaxon logS -2.6 ALOGPS pKa (Strongest Acidic) 16.11 Chemaxon pKa (Strongest Basic) 7.83 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 69.39 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 58.29 m3·mol-1 Chemaxon Polarizability 25.04 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon