Lodoxamide tromethamineProduct ingredient for Lodoxamide
- Name
- Lodoxamide tromethamine
- Drug Entry
- Lodoxamide
Lodoxamide is a mast-cell stabilizer for topical administration into the eye. Mast-cell stabilizers, first one approved being cromolyn sodium, are used in treatment of ocular hypersensitivity reactions such as vernal conjunctivitis. These conditions often require treatment with anti-inflammatory medications such as ophthalmic NSAIDs or topical steroids which may cause systemic or toxic effects long-term. Although less effective than topical steroids at decreasing inflammation, mast-cell stabilizers offer another treatment option and exhibit minimal adverse effects. Lodoxamide is marketed under the brand name Alomide by Alcon.
- Accession Number
- DBSALT001178
- Structure
Structure for Lodoxamide tromethamine (DBSALT001178)
- Synonyms
- Lodoxamide trometamol
- UNII
- 50LV9A548L
- CAS Number
- 63610-09-3
- Weight
- Average: 553.91
Monoisotopic: 553.1422991 - Chemical Formula
- C19H28ClN5O12
- InChI Key
- JJOFNSLZHKIJEV-UHFFFAOYSA-N
- InChI
- InChI=1S/C11H6ClN3O6.2C4H11NO3/c12-7-5(14-8(16)10(18)19)1-4(3-13)2-6(7)15-9(17)11(20)21;2*5-4(1-6,2-7)3-8/h1-2H,(H,14,16)(H,15,17)(H,18,19)(H,20,21);2*6-8H,1-3,5H2
- IUPAC Name
- bis(2-amino-2-(hydroxymethyl)propane-1,3-diol); {[3-(carboxyformamido)-2-chloro-5-cyanophenyl]carbamoyl}formic acid
- SMILES
- NC(CO)(CO)CO.NC(CO)(CO)CO.OC(=O)C(=O)NC1=CC(=CC(NC(=O)C(O)=O)=C1Cl)C#N
- External Links
- ChemSpider
- 9367206
- ChEMBL
- CHEMBL3989725
- Predicted Properties
Property Value Source Water Solubility 0.0361 mg/mL ALOGPS logP 0.72 ALOGPS logP 0.83 Chemaxon logS -3.9 ALOGPS pKa (Strongest Acidic) -6.7 Chemaxon pKa (Strongest Basic) 0.73 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 4 Chemaxon Polar Surface Area 156.59 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 69.9 m3·mol-1 Chemaxon Polarizability 26.52 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon