Carvedilol phosphateProduct ingredient for Carvedilol
- Name
- Carvedilol phosphate
- Drug Entry
- Carvedilol
Carvedilol is a racemic mixture where the S(-) enantiomer is both a beta and alpha-1 adrenoceptor blocker, and the R(+) enantiomer is an alpha-1 adrenoceptor blocker.5,6 It is currently used to treat heart failure, left ventricular dysfunction, and hypertension.5,6 The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the treatment of moderate hypertension.4
Carvedilol was granted FDA approval on 14 September 1995.5
- Accession Number
- DBSALT001201
- Structure
Structure for Carvedilol phosphate (DBSALT001201)
- Synonyms
- Not Available
- UNII
- EQT531S367
- CAS Number
- 610309-89-2
- Weight
- Average: 1026.967
Monoisotopic: 1026.342870484 - Chemical Formula
- C48H60N4O17P2
- InChI Key
- LHNYXTULDSJZRB-UHFFFAOYSA-N
- InChI
- InChI=1S/2C24H26N2O4.2H3O4P.H2O/c2*1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20;2*1-5(2,3)4;/h2*2-12,17,25-27H,13-16H2,1H3;2*(H3,1,2,3,4);1H2
- IUPAC Name
- bis(1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol) bis(phosphoric acid) hydrate
- SMILES
- O.OP(O)(O)=O.OP(O)(O)=O.COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=C1C1=C(N2)C=CC=C1.COC1=CC=CC=C1OCCNCC(O)COC1=CC=CC2=C1C1=C(N2)C=CC=C1
- External Links
- ChemSpider
- 10128639
- Predicted Properties
Property Value Source Water Solubility 0.00444 mg/mL ALOGPS logP 3.05 ALOGPS logP 3.42 Chemaxon logS -5 ALOGPS pKa (Strongest Acidic) 14.03 Chemaxon pKa (Strongest Basic) 8.74 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 75.74 Å2 Chemaxon Rotatable Bond Count 20 Chemaxon Refractivity 115.64 m3·mol-1 Chemaxon Polarizability 44.49 Å3 Chemaxon Number of Rings 8 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon