Miconazole nitrateProduct ingredient for Miconazole

Miconazole is a broad-spectrum azole antifungal with some activity against Gram-positive bacteria as well.³ It is widely used to treat mucosal yeast infections, including both oral and vaginal infections; although intravenous miconazole is no longer available, a wide variety of suppositories, creams, gels, and tablet-based products are available.^{13,14,15,16,17} Miconazole is thought to act primarily through the inhibition of fungal CYP450 14α-lanosterol demethylase activity.^3,4

Miconazole was first synthesized in 1969 and first granted FDA approval on January 8, 1974, for sale by INSIGHT Pharmaceuticals as a topical cream.^12,13 It is currently available as a variety of prescription and over the counter products. Despite having been in clinical use for an extended period, resistance to miconazole among susceptible organisms is relatively low.³