Viloxazine hydrochlorideProduct ingredient for Viloxazine

Name
Viloxazine hydrochloride
Drug Entry
Viloxazine

Viloxazine is a selective norepinephrine reuptake inhibitor.7 For decades, an immediate-release formulation of viloxazine has been used in Europe as an antidepressant. It was first approved in the UK in 1974; however, the immediate-release formulation was discontinued due to business reasons unrelated to drug safety and efficacy. In the US, viloxazine was assigned an orphan drug designation in 1984 under the brand name CATATROL: while this product was intended to treat cataplexy and narcolepsy, the drug was never approved for these therapeutic indications. In April 2021, an extended-release formulation of viloxazine under the brand name QELBREE was approved by the FDA for the treatment of attention deficit hyperactivity disorder (ADHD).6

Accession Number
DBSALT001262
Structure
Synonyms
Viloxazine HCl
UNII
OQW30I1332
CAS Number
35604-67-2
Weight
Average: 273.76
Monoisotopic: 273.1131712
Chemical Formula
C13H20ClNO3
InChI Key
HJOCKFVCMLCPTP-UHFFFAOYSA-N
InChI
InChI=1S/C13H19NO3.ClH/c1-2-15-12-5-3-4-6-13(12)17-10-11-9-14-7-8-16-11;/h3-6,11,14H,2,7-10H2,1H3;1H
IUPAC Name
2-[(2-ethoxyphenoxy)methyl]morpholine hydrochloride
SMILES
Cl.CCOC1=CC=CC=C1OCC1CNCCO1
ChemSpider
64514
ChEMBL
CHEMBL2106483
Predicted Properties
PropertyValueSource
Water Solubility1.24 mg/mLALOGPS
logP1.71ALOGPS
logP1.49ChemAxon
logS-2.3ALOGPS
pKa (Strongest Basic)8.19ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area39.72 Å2ChemAxon
Rotatable Bond Count5ChemAxon
Refractivity65.2 m3·mol-1ChemAxon
Polarizability26.2 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon