Ramosetron hydrochlorideProduct ingredient for Ramosetron
- Name
- Ramosetron hydrochloride
- Drug Entry
- Ramosetron
Ramosetron is a serotonin 5-HT3 receptor antagonist commonly employed to treat nausea and vomiting, in addition to certain diarrheal conditions. It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondansetron. Currently, ramosetron is only approved for use Japan and in certain Southeast Asian countries.
- Accession Number
- DBSALT001285
- Structure
Structure for Ramosetron hydrochloride (DBSALT001285)
- Synonyms
- Ramosetron HCl
- UNII
- 9551LHD87E
- CAS Number
- 132907-72-3
- Weight
- Average: 315.8
Monoisotopic: 315.1138399 - Chemical Formula
- C17H18ClN3O
- InChI Key
- XIXYTCLDXQRHJO-RFVHGSKJSA-N
- InChI
- InChI=1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1
- IUPAC Name
- (5R)-5-(1-methyl-1H-indole-3-carbonyl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole hydrochloride
- SMILES
- Cl.CN1C=C(C(=O)[C@@H]2CCC3=C(C2)N=CN3)C2=C1C=CC=C2
- External Links
- KEGG Drug
- D02016
- ChemSpider
- 97111
- ChEBI
- 32088
- ChEMBL
- CHEMBL3181841
- Predicted Properties
Property Value Source Water Solubility 0.0696 mg/mL ALOGPS logP 2.22 ALOGPS logP 2.24 Chemaxon logS -3.6 ALOGPS pKa (Strongest Acidic) 12.68 Chemaxon pKa (Strongest Basic) 6.36 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 50.68 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 82.14 m3·mol-1 Chemaxon Polarizability 31.2 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon