Clavulanate potassiumProduct ingredient for Clavulanic acid
- Name
- Clavulanate potassium
- Drug Entry
- Clavulanic acid
Clavulanic acid is a beta-lactamase inhibitor that is frequently combined with Amoxicillin or Ticarcillin to fight antibiotic resistance by preventing their degradation by beta-lactamase enzymes, broadening their spectrum of susceptible bacterial infections.8 Clavulanic acid is derived from the organism Streptomyces clavuligerus.1When it is combined with amoxicillin, clavulanic acid is frequently known as Augmentin, Co-Amoxiclav, or Clavulin.10,13,15
- Accession Number
- DBSALT001302
- Structure
Structure for Clavulanate potassium (DBSALT001302)
- Synonyms
- Potassium Clavulanate
- UNII
- Q42OMW3AT8
- CAS Number
- 61177-45-5
- Weight
- Average: 237.252
Monoisotopic: 237.00395385 - Chemical Formula
- C8H8KNO5
- InChI Key
- ABVRVIZBZKUTMK-JSYANWSFSA-M
- InChI
- InChI=1S/C8H9NO5.K/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4;/h1,6-7,10H,2-3H2,(H,12,13);/q;+1/p-1/b4-1-;/t6-,7-;/m1./s1
- IUPAC Name
- potassium (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate
- SMILES
- [K+].OC\C=C1/O[C@@H]2CC(=O)N2[C@H]1C([O-])=O
- External Links
- ChemSpider
- 4939512
- ChEBI
- 85264
- ChEMBL
- CHEMBL1003
- Wikipedia
- Clavulanic_acid
- Predicted Properties
Property Value Source Water Solubility 443.0 mg/mL ALOGPS logP -0.74 ALOGPS logP -1.5 Chemaxon logS 0.27 ALOGPS pKa (Strongest Acidic) 3.32 Chemaxon pKa (Strongest Basic) -2.6 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 89.9 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 55.09 m3·mol-1 Chemaxon Polarizability 17.89 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon