Ziconotide acetateProduct ingredient for Ziconotide

Ziconotide (also known as SNX-111) is a neurotoxic peptide derived from the cone snail Conus magus comprising 25 amino acids with three disulphide bonds.^7,18 Other such peptides, collectively termed conotoxins, exist, and some have shown efficacy in binding specific subsets of calcium channels; ziconotide is used in part because it can be synthesized without loss of proper bond formation or structural elements.^5,6 Ziconotide is used to manage severe chronic pain refractory to other methods, through its ability to inhibit N-type calcium channels involved in nociceptive signalling.^{5,7,8,9,12,14,18}

Ziconotide was granted FDA approval on December 28, 2004 for marketing by TerSera therapeutics LLC. under the name Prialt.¹⁸ To date, ziconotide is the only calcium channel blocking peptide approved for use by the FDA.⁷

ChEMBL

CHEMBL1795072

Wikipedia

Ziconotide