Dexmethylphenidate hydrochlorideProduct ingredient for Dexmethylphenidate

Name
Dexmethylphenidate hydrochloride
Drug Entry
Dexmethylphenidate

Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 20022. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant5. It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)Label,2. The d-isomer is thought to have greater effect with fewer side effects than the l-isomer or the racemic mixture2.

Accession Number
DBSALT001458
Structure
Thumb
Synonyms
Dexmethylphenidate HCl
UNII
1678OK0E08
CAS Number
19262-68-1
Weight
Average: 269.77
Monoisotopic: 269.1182566
Chemical Formula
C14H20ClNO2
InChI Key
JUMYIBMBTDDLNG-OJERSXHUSA-N
InChI
InChI=1S/C14H19NO2.ClH/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12;/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3;1H/t12-,13-;/m1./s1
IUPAC Name
methyl (2R)-2-phenyl-2-[(2R)-piperidin-2-yl]acetate hydrochloride
SMILES
Cl.[H][C@@](C(=O)OC)(C1=CC=CC=C1)[C@@]1([H])CCCCN1
ChemSpider
135806
ChEMBL
CHEMBL904
Wikipedia
Dexmethylphenidate
Predicted Properties
PropertyValueSource
Water Solubility0.182 mg/mLALOGPS
logP1.47ALOGPS
logP2.25ChemAxon
logS-3.1ALOGPS
pKa (Strongest Basic)9.09ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area38.33 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity66.73 m3·mol-1ChemAxon
Polarizability26.15 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon