Cinacalcet hydrochlorideProduct ingredient for Cinacalcet
- Name
- Cinacalcet hydrochloride
- Drug Entry
- Cinacalcet
Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
- Accession Number
- DBSALT001463
- Structure
Structure for Cinacalcet hydrochloride (DBSALT001463)
- Synonyms
- Cinacalcet HCl
- UNII
- 1K860WSG25
- CAS Number
- 364782-34-3
- Weight
- Average: 393.88
Monoisotopic: 393.1471119 - Chemical Formula
- C22H23ClF3N
- InChI Key
- QANQWUQOEJZMLL-PKLMIRHRSA-N
- InChI
- InChI=1S/C22H22F3N.ClH/c1-16(20-13-5-10-18-9-2-3-12-21(18)20)26-14-6-8-17-7-4-11-19(15-17)22(23,24)25;/h2-5,7,9-13,15-16,26H,6,8,14H2,1H3;1H/t16-;/m1./s1
- IUPAC Name
- [(1R)-1-(naphthalen-1-yl)ethyl]({3-[3-(trifluoromethyl)phenyl]propyl})amine hydrochloride
- SMILES
- Cl.[H][C@](C)(NCCCC1=CC(=CC=C1)C(F)(F)F)C1=CC=CC2=CC=CC=C12
- External Links
- ChemSpider
- 137742
- ChEBI
- 48391
- ChEMBL
- CHEMBL1200776
- Wikipedia
- Cinacalcet
- Predicted Properties
Property Value Source Water Solubility 5.59e-05 mg/mL ALOGPS logP 5.57 ALOGPS logP 6.27 Chemaxon logS -6.8 ALOGPS pKa (Strongest Basic) 10.01 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 1 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 12.03 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 100.12 m3·mol-1 Chemaxon Polarizability 37.11 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon