Methicillin sodiumProduct ingredient for Meticillin
- Name
- Methicillin sodium
- Drug Entry
- Meticillin
One of the penicillins which is resistant to penicillinase but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection.
- Accession Number
- DBSALT001467
- Structure
- Synonyms
- Not Available
- UNII
- AO9YF4MN30
- CAS Number
- 7246-14-2
- Weight
- Average: 420.41
Monoisotopic: 420.09671648 - Chemical Formula
- C17H21N2NaO7S
- InChI Key
- NRZPASQBOYNGHR-HWROMZCQSA-M
- InChI
- InChI=1S/C17H20N2O6S.Na.H2O/c1-17(2)12(16(22)23)19-14(21)11(15(19)26-17)18-13(20)10-8(24-3)6-5-7-9(10)25-4;;/h5-7,11-12,15H,1-4H3,(H,18,20)(H,22,23);;1H2/q;+1;/p-1/t11-,12+,15-;;/m1../s1
- IUPAC Name
- sodium N-[(2S,5R,6R)-2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-6-yl]-2,6-dimethoxybenzene-1-carboximidate hydrate
- SMILES
- O.[Na+].[H][C@]12SC(C)(C)[C@@]([H])(N1C(=O)[C@@]2([H])N=C([O-])C1=C(OC)C=CC=C1OC)C(O)=O
- External Links
- KEGG Compound
- C13973
- ChemSpider
- 390012
- ChEBI
- 34836
- ChEMBL
- CHEMBL3181832
- Wikipedia
- Methicillin
- Predicted Properties
Property Value Source Water Solubility 0.188 mg/mL ALOGPS logP 2.16 ALOGPS logP 1.6 Chemaxon logS -3.3 ALOGPS pKa (Strongest Acidic) 2.96 Chemaxon pKa (Strongest Basic) -0.076 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 111.49 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 104.47 m3·mol-1 Chemaxon Polarizability 36.59 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon