Cefovecin sodiumProduct ingredient for Cefovecin
- Name
- Cefovecin sodium
- Drug Entry
- Cefovecin
Cefovecin is a cephalosporin antibiotic used for the treatment of skin infections in cats and dogs. It is the first single-dose injectable antibiotic for dogs and cats that assures owner compliance with dosing for the animal. It is used for the treatment of skin infections caused by Pasturella multocida in cats, and Staphylococcus intermedius/S. canis in dogs. The advantage of using injectable antibiotics is not missing a dose that can allow partially resistant microbes to recover during missed doses. However, these injectable agents can present long-lasting subtherapeutic concentrations after the resolution of infection. The presence of low concentrations of antibiotics is related to the development of microbial resistance.
- Accession Number
- DBSALT001671
- Structure
- Synonyms
- Cefovecin sodium
- External IDs
- UK 287074-02 / UK-287,074-02
- UNII
- DL8Q24959P
- CAS Number
- 141195-77-9
- Weight
- Average: 475.47
Monoisotopic: 475.05961995 - Chemical Formula
- C17H18N5NaO6S2
- InChI Key
- QRIBXVGHDLFNNE-VQWMGBAQSA-M
- InChI
- InChI=1S/C17H19N5O6S2.Na/c1-27-21-10(8-6-30-17(18)19-8)13(23)20-11-14(24)22-12(16(25)26)7(5-29-15(11)22)9-3-2-4-28-9;/h6,9,11,15H,2-5H2,1H3,(H2,18,19)(H,20,23)(H,25,26);/q;+1/p-1/b21-10-;/t9-,11+,15+;/m0./s1
- IUPAC Name
- sodium (6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-3-[(2S)-oxolan-2-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
- SMILES
- [Na+].[H][C@]12SCC([C@@H]3CCCO3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\C1=CSC(N)=N1)C([O-])=O
- External Links
- Predicted Properties
Property Value Source Water Solubility 0.175 mg/mL ALOGPS logP 1.08 ALOGPS logP -0.77 Chemaxon logS -3.4 ALOGPS pKa (Strongest Acidic) 2.8 Chemaxon pKa (Strongest Basic) 3.62 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 9 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 159.27 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 118.76 m3·mol-1 Chemaxon Polarizability 42.43 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon