Cefovecin sodiumProduct ingredient for Cefovecin

Name
Cefovecin sodium
Drug Entry
Cefovecin

Cefovecin is a cephalosporin antibiotic used for the treatment of skin infections in cats and dogs. It is the first single-dose injectable antibiotic for dogs and cats that assures owner compliance with dosing for the animal. It is used for the treatment of skin infections caused by Pasturella multocida in cats, and Staphylococcus intermedius/S. canis in dogs. The advantage of using injectable antibiotics is not missing a dose that can allow partially resistant microbes to recover during missed doses. However, these injectable agents can present long-lasting subtherapeutic concentrations after the resolution of infection. The presence of low concentrations of antibiotics is related to the development of microbial resistance.

Accession Number
DBSALT001671
Structure
Synonyms
Cefovecin sodium
External IDs
UK 287074-02 / UK-287,074-02
UNII
DL8Q24959P
CAS Number
141195-77-9
Weight
Average: 475.47
Monoisotopic: 475.05961995
Chemical Formula
C17H18N5NaO6S2
InChI Key
QRIBXVGHDLFNNE-VQWMGBAQSA-M
InChI
InChI=1S/C17H19N5O6S2.Na/c1-27-21-10(8-6-30-17(18)19-8)13(23)20-11-14(24)22-12(16(25)26)7(5-29-15(11)22)9-3-2-4-28-9;/h6,9,11,15H,2-5H2,1H3,(H2,18,19)(H,20,23)(H,25,26);/q;+1/p-1/b21-10-;/t9-,11+,15+;/m0./s1
IUPAC Name
sodium (6R,7R)-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-3-[(2S)-oxolan-2-yl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
SMILES
[Na+].[H][C@]12SCC([C@@H]3CCCO3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\C1=CSC(N)=N1)C([O-])=O
KEGG Compound
C13142
ChemSpider
4589883
ChEBI
31375
Wikipedia
Cefovecin
Predicted Properties
PropertyValueSource
Water Solubility0.175 mg/mLALOGPS
logP1.08ALOGPS
logP-0.77Chemaxon
logS-3.4ALOGPS
pKa (Strongest Acidic)2.8Chemaxon
pKa (Strongest Basic)3.62Chemaxon
Physiological Charge-1Chemaxon
Hydrogen Acceptor Count9Chemaxon
Hydrogen Donor Count2Chemaxon
Polar Surface Area159.27 Å2Chemaxon
Rotatable Bond Count6Chemaxon
Refractivity118.76 m3·mol-1Chemaxon
Polarizability42.43 Å3Chemaxon
Number of Rings4Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterNoChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleYesChemaxon