Zolazepam hydrochlorideProduct ingredient for Zolazepam
- Name
- Zolazepam hydrochloride
- Drug Entry
- Zolazepam
Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the α2 adrenoceptor agonist xylazine. It is around four times the potency of diazepam but it is both water-soluble and un-ionized at physiological pH meaning that its onset is very fast.
- Accession Number
- DBSALT001709
- Structure
Structure for Zolazepam hydrochloride (DBSALT001709)
- Synonyms
- Zolazepam HCl / Zolazepam hydrochloride
- UNII
- 45SJ093Q1N
- CAS Number
- 33754-49-3
- Weight
- Average: 322.77
Monoisotopic: 322.099667 - Chemical Formula
- C15H16ClFN4O
- InChI Key
- NJERAXSSDSHLGE-UHFFFAOYSA-N
- InChI
- InChI=1S/C15H15FN4O.ClH/c1-9-13-14(10-6-4-5-7-11(10)16)17-8-12(21)19(2)15(13)20(3)18-9;/h4-7H,8H2,1-3H3;1H
- IUPAC Name
- 4-(2-fluorophenyl)-1,3,8-trimethyl-1H,6H,7H,8H-pyrazolo[3,4-e][1,4]diazepin-7-one hydrochloride
- SMILES
- Cl.CN1N=C(C)C2=C1N(C)C(=O)CN=C2C1=CC=CC=C1F
- External Links
- ChemSpider
- 64506
- ChEMBL
- CHEMBL2107559
- Predicted Properties
Property Value Source Water Solubility 0.269 mg/mL ALOGPS logP 1.76 ALOGPS logP 1.26 Chemaxon logS -3 ALOGPS pKa (Strongest Basic) 2.38 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 50.49 Å2 Chemaxon Rotatable Bond Count 1 Chemaxon Refractivity 87.97 m3·mol-1 Chemaxon Polarizability 28.9 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon