Perampanel hydrateProduct ingredient for Perampanel
- Name
- Perampanel hydrate
- Drug Entry
- Perampanel
Perampanel is a noncompetitive AMPA glutamate receptor antagonist. It is marketed under the name Fycompa™ and is indicated as an adjunct in patients over 12 years old for the treatment of partial-onset seizures that may or may not occur with generalized seizures. The FDA label includes an important black-boxed warning of serious or life-threatening behavioral and psychiatric reactions in patients taking Fycompa™.
- Accession Number
- DBSALT001824
- Structure
Structure for Perampanel hydrate (DBSALT001824)
- Synonyms
- Not Available
- UNII
- 8LIX22217M
- CAS Number
- 1571982-04-1
- Weight
- Average: 1451.617
Monoisotopic: 1450.517742513 - Chemical Formula
- C92H66N12O7
- InChI Key
- PDWMJDKMSASBNE-UHFFFAOYSA-N
- InChI
- InChI=1S/4C23H15N3O.3H2O/c4*24-15-17-8-4-5-11-20(17)21-14-18(22-12-6-7-13-25-22)16-26(23(21)27)19-9-2-1-3-10-19;;;/h4*1-14,16H;3*1H2
- IUPAC Name
- tetrakis(2-{6'-oxo-1'-phenyl-1',6'-dihydro-[2,3'-bipyridine]-5'-yl}benzonitrile) trihydrate
- SMILES
- O.O.O.O=C1N(C=C(C=C1C1=C(C=CC=C1)C#N)C1=NC=CC=C1)C1=CC=CC=C1.O=C1N(C=C(C=C1C1=C(C=CC=C1)C#N)C1=NC=CC=C1)C1=CC=CC=C1.O=C1N(C=C(C=C1C1=C(C=CC=C1)C#N)C1=NC=CC=C1)C1=CC=CC=C1.O=C1N(C=C(C=C1C1=C(C=CC=C1)C#N)C1=NC=CC=C1)C1=CC=CC=C1
- External Links
- Predicted Properties
Property Value Source Water Solubility 0.0056 mg/mL ALOGPS logP 3.54 ALOGPS logP 4.11 Chemaxon logS -4.8 ALOGPS pKa (Strongest Basic) 4.01 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 56.99 Å2 Chemaxon Rotatable Bond Count 12 Chemaxon Refractivity 104.74 m3·mol-1 Chemaxon Polarizability 38.02 Å3 Chemaxon Number of Rings 16 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon