Choline fenofibrateProduct ingredient for Fenofibric acid

Name
Choline fenofibrate
Drug Entry
Fenofibric acid

Fenofibric acid is a lipid-lowering agent that is used in severe hypertriglyceridemia, primary hyperlipidemia, and mixed dyslipidemia. It works to decrease elevated low-density lipoprotein cholesterol, total cholesterol, triglycerides, apolipoprotein B, while increasing high-density lipoprotein cholesterol.1,5 Due to its high hydrophilicity and poor absorption profile,1 prodrug ,fenofibrate, and other conjugated compounds of fenofibric acid, such as choline fenofibrate, have been developed for improved solubility, gastrointestinal absorption, and bioavailability, and more convenient administration.1,3

Accession Number
DBSALT001885
Structure
Thumb
Synonyms
Fenofibric acid choline salt
External IDs
ABT-335
UNII
4BMH7IZT98
CAS Number
856676-23-8
Weight
Average: 421.92
Monoisotopic: 421.1656007
Chemical Formula
C22H28ClNO5
InChI Key
JWAZHODZSADEHB-UHFFFAOYSA-M
InChI
InChI=1S/C17H15ClO4.C5H14NO/c1-17(2,16(20)21)22-14-9-5-12(6-10-14)15(19)11-3-7-13(18)8-4-11;1-6(2,3)4-5-7/h3-10H,1-2H3,(H,20,21);7H,4-5H2,1-3H3/q;+1/p-1
IUPAC Name
(2-hydroxyethyl)trimethylazanium 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
SMILES
C[N+](C)(C)CCO.CC(C)(OC1=CC=C(C=C1)C(=O)C1=CC=C(Cl)C=C1)C([O-])=O
ChemSpider
9525637
ChEMBL
CHEMBL1201745
Predicted Properties
PropertyValueSource
Water Solubility0.000678 mg/mLALOGPS
logP0.76ALOGPS
logP4.36ChemAxon
logS-5.8ALOGPS
pKa (Strongest Acidic)3.1ChemAxon
pKa (Strongest Basic)-4.9ChemAxon
Physiological Charge-1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area66.43 Å2ChemAxon
Rotatable Bond Count7ChemAxon
Refractivity94.03 m3·mol-1ChemAxon
Polarizability31.94 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon