Tolperisone hydrochlorideProduct ingredient for Tolperisone

Name
Tolperisone hydrochloride
Drug Entry
Tolperisone

Tolperisone is an oral, centrally acting muscle relaxant. Its precise mechanism is not completely understood, though it blocks sodium and calcium channels. It possesses a high affinity for nervous system tissue, reaching highest concentrations in brain stem, spinal cord and peripheral nerves. Based on existing clinical data, Tolperisone is not sedating and does not interact with alcohol.

Accession Number
DBSALT002004
Structure
Thumb
Synonyms
Not Available
UNII
8Z075K2TIG
CAS Number
3644-61-9
Weight
Average: 281.82
Monoisotopic: 281.1546421
Chemical Formula
C16H24ClNO
InChI Key
ZBUVYROEHQQAKL-UHFFFAOYSA-N
InChI
InChI=1S/C16H23NO.ClH/c1-13-6-8-15(9-7-13)16(18)14(2)12-17-10-4-3-5-11-17;/h6-9,14H,3-5,10-12H2,1-2H3;1H
IUPAC Name
2-methyl-1-(4-methylphenyl)-3-(piperidin-1-yl)propan-1-one hydrochloride
SMILES
Cl.CC(CN1CCCCC1)C(=O)C1=CC=C(C)C=C1
ChemSpider
83919
ChEBI
32244
ChEMBL
CHEMBL1395150
Predicted Properties
PropertyValueSource
Water Solubility0.167 mg/mLALOGPS
logP3.75ALOGPS
logP3.57ChemAxon
logS-3.2ALOGPS
pKa (Strongest Acidic)16.51ChemAxon
pKa (Strongest Basic)8.78ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area20.31 Å2ChemAxon
Rotatable Bond Count4ChemAxon
Refractivity76.35 m3·mol-1ChemAxon
Polarizability29.14 Å3ChemAxon
Number of Rings2ChemAxon
Bioavailability1ChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon