Ribociclib hydrochlorideProduct ingredient for Ribociclib
- Name
- Ribociclib hydrochloride
- Drug Entry
- Ribociclib
Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced precision may play a role in ensuring that cancer cells do not continue to replicate uncontrollably. Ribociclib was approved by the U.S. FDA in March, 2017 as Kisqali.
- Accession Number
- DBSALT002059
- Structure
Structure for Ribociclib hydrochloride (DBSALT002059)
- Synonyms
- Not Available
- UNII
- 63YF7YKW7E
- CAS Number
- 1211443-80-9
- Weight
- Average: 471.01
Monoisotopic: 470.2309354 - Chemical Formula
- C23H31ClN8O
- InChI Key
- JZRSIQPIKASMEV-UHFFFAOYSA-N
- InChI
- InChI=1S/C23H30N8O.ClH/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30;/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28);1H
- IUPAC Name
- 7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide hydrochloride
- SMILES
- Cl.CN(C)C(=O)C1=CC2=CN=C(NC3=CC=C(C=N3)N3CCNCC3)N=C2N1C1CCCC1
- External Links
- ChemSpider
- 32702923
- Predicted Properties
Property Value Source Water Solubility 0.231 mg/mL ALOGPS logP 2.5 ALOGPS logP 2.38 Chemaxon logS -3.3 ALOGPS pKa (Strongest Acidic) 11.59 Chemaxon pKa (Strongest Basic) 8.87 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 91.21 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 125.59 m3·mol-1 Chemaxon Polarizability 49.1 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon