Tivozanib hydrochlorideProduct ingredient for Tivozanib
- Name
- Tivozanib hydrochloride
- Drug Entry
- Tivozanib
Renal cell carcinoma (RCC) is responsible for 3% of cancer cases2 and is one of the 10 most common cancers in adults. The average age of diagnosis is between age 65 to 74.10 Tivozanib, also known as FOTIVDA, is a kinase inhibitor developed to treat adult patients with relapsed or refractory advanced renal cell carcinoma (RCC) after prior failed systemic therapies. It was approved on March 10, 2021 by the FDA. Marketed by Aveo Oncology, tivozanib is a promising therapy for individuals with RCC who have not been treated successfully with other therapies.9
- Accession Number
- DBSALT002078
- Structure
Structure for Tivozanib hydrochloride (DBSALT002078)
- Synonyms
- Tivozanib HCl / Tivozanib HCl hydrate / Tivozanib hydrochloride / Tivozanib hydrochloride hydrate / Tivozanib hydrochloride monohydrate
- UNII
- 8A9H4VK35Z
- CAS Number
- 682745-41-1
- Weight
- Average: 509.34
Monoisotopic: 508.0916398 - Chemical Formula
- C22H22Cl2N4O6
- InChI Key
- RQXMKRRBJITKRN-UHFFFAOYSA-N
- InChI
- InChI=1S/C22H19ClN4O5.ClH.H2O/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18;;/h4-11H,1-3H3,(H2,25,26,27,28);1H;1H2
- IUPAC Name
- 1-{2-chloro-4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-3-(5-methyl-1,2-oxazol-3-yl)urea hydrate hydrochloride
- SMILES
- O.Cl.COC1=C(OC)C=C2C(OC3=CC(Cl)=C(NC(=O)NC4=NOC(C)=C4)C=C3)=CC=NC2=C1
- External Links
- ChemSpider
- 9722757
- ChEMBL
- CHEMBL2105756
- Predicted Properties
Property Value Source Water Solubility 0.0521 mg/mL ALOGPS logP 4.25 ALOGPS logP 4.22 Chemaxon logS -3.9 ALOGPS pKa (Strongest Acidic) 8.27 Chemaxon pKa (Strongest Basic) 5.89 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 107.74 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 120.85 m3·mol-1 Chemaxon Polarizability 44.2 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon