Propiverine hydrochlorideProduct ingredient for Propiverine

Name
Propiverine hydrochloride
Drug Entry
Propiverine

Propiverine is a widely used antimuscarinic drug with a mixed mode of action in the treatment of symptoms associated with overactive bladder (OAB) 1.

Overactive bladder (OAB) is a chronic condition of the lower urinary tract characterized by urinary urgency, increased frequency of urination, and nocturia (frequent waking during the night to urinate). OAB has a negative impact on quality of life and may lead to leakage and inconvenient urinary accidents 15, 16. Overactive bladder syndrome affects millions of elderly individuals in the United States and shows equal prevalence in men and women. The impact of OAB on quality of life is sometimes devastating, especially to elderly patients with other medical conditions 16.

Propiverine hydrochloride is a bladder detrusor muscle relaxant drug with dual antimuscarinic and calcium-modulating properties for the treatment of OAB 7.

Accession Number
DBSALT002169
Structure
Synonyms
Propiverine HCl
UNII
DC4GZD10H3
CAS Number
54556-98-8
Weight
Average: 403.95
Monoisotopic: 403.1914215
Chemical Formula
C23H30ClNO3
InChI Key
KFUJMHHNLGCTIJ-UHFFFAOYSA-N
InChI
InChI=1S/C23H29NO3.ClH/c1-3-18-26-23(19-10-6-4-7-11-19,20-12-8-5-9-13-20)22(25)27-21-14-16-24(2)17-15-21;/h4-13,21H,3,14-18H2,1-2H3;1H
IUPAC Name
1-methylpiperidin-4-yl 2,2-diphenyl-2-propoxyacetate hydrochloride
SMILES
Cl.CCCOC(C(=O)OC1CCN(C)CC1)(C1=CC=CC=C1)C1=CC=CC=C1
KEGG Drug
D01007
ChemSpider
37537
ChEBI
8494
ChEMBL
CHEMBL2359059
Predicted Properties
PropertyValueSource
Water Solubility0.00635 mg/mLALOGPS
logP4.16ALOGPS
logP4.25Chemaxon
logS-4.8ALOGPS
pKa (Strongest Basic)8.72Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count3Chemaxon
Hydrogen Donor Count0Chemaxon
Polar Surface Area38.77 Å2Chemaxon
Rotatable Bond Count8Chemaxon
Refractivity107.73 m3·mol-1Chemaxon
Polarizability41.88 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleYesChemaxon
MDDR-like RuleYesChemaxon