Baclofen hydrochlorideProduct ingredient for Baclofen
- Name
- Baclofen hydrochloride
- Drug Entry
- Baclofen
Baclofen is a gamma-aminobutyric acid (GABA) agonist used as a skeletal muscle relaxant. Although originally designed in 1962 to treat epilepsy, baclofen was not effective in treating this condition but instead was shown to reduce spasticity in selected patients.8 Baclofen was reintroduced in 1971 as a treatment for spasticity and was later approved by the FDA in 1977.6,8 Baclofen is used to manage severe muscle spasms of cerebral or spinal cord origins, including multiple sclerosis and traumatic brain injury.11
Baclofen was investigated for use in alcohol dependence and withdrawal; however, evidence is limited and there is inconsistent evidence to suggest its clinical efficacy in managing alcohol dependence or withdrawal symptoms.1,2,8
- Accession Number
- DBSALT002256
- Structure
- Synonyms
- Not Available
- UNII
- 64OSE3996V
- CAS Number
- 28311-31-1
- Weight
- Average: 250.12
Monoisotopic: 249.0323341 - Chemical Formula
- C10H13Cl2NO2
- InChI Key
- WMNUVYYLMCMHLU-UHFFFAOYSA-N
- InChI
- InChI=1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H
- IUPAC Name
- 4-amino-3-(4-chlorophenyl)butanoic acid hydrochloride
- SMILES
- Cl.NCC(CC(O)=O)C1=CC=C(Cl)C=C1
- External Links
- ChemSpider
- 5035036
- ChEMBL
- CHEMBL1897150
- Predicted Properties
Property Value Source Water Solubility 0.712 mg/mL ALOGPS logP -0.82 ALOGPS logP -0.78 Chemaxon logS -2.5 ALOGPS pKa (Strongest Acidic) 3.89 Chemaxon pKa (Strongest Basic) 9.79 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 63.32 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 54.83 m3·mol-1 Chemaxon Polarizability 21.12 Å3 Chemaxon Number of Rings 1 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon