Midazolam maleateProduct ingredient for Midazolam

Midazolam is a short-acting hypnotic-sedative drug with anxiolytic, muscle relaxant, anticonvulsant, sedative, hypnotic, and amnesic properties.⁶ It belongs to a class of drugs called benzodiazepines. This drug is unique from others in this class due to its rapid onset of effects and short duration of action.⁶ Midazolam is available by oral, rectal, intranasal, intramuscular (IM), and intravenous (IV) routes and has been used in various biomedical applications, including dentistry, cardiac surgery, and endoscopic procedures as pre-anesthetic medication, and as an adjunct to local anesthesia.²¹

This drug was initially approved by the US FDA in 1985, and has been approved for various indications since.¹⁹ In late 2018, the intramuscular preparation was approved by the FDA for the treatment of status epilepticus in adults.¹⁹ In May 2019, the nasal spray of midazolam was approved for the acute treatment of distinctive intermittent, stereotypic seizure episodes in patients 12 years of age and older.⁸ Midazolam is considered a schedule IV drug in the United States due to the low potential for abuse and low risk of dependence.¹⁰