Nafamostat mesylateProduct ingredient for Nafamostat
- Name
- Nafamostat mesylate
- Drug Entry
- Nafamostat
Nafamostat is a synthetic serine protease inhibitor that is commonly formulated with hydrochloric acid due to its basic properties. It has been used in trials studying the prevention of Liver Transplantation and Postreperfusion Syndrome. The use of nafamostat in Asian countries is approved as an anticoagulant therapy for patients undergoing continuous renal replacement therapy due to acute kidney injury.
- Accession Number
- DBSALT002384
- Structure
Structure for Nafamostat mesylate (DBSALT002384)
- Synonyms
- Nafamostat dimethanesulfonate / Nafamostat mesilate / Nafamostat mesylate
- External IDs
- FUT 175 / FUT-175
- UNII
- 1D2T74921W
- CAS Number
- 82956-11-4
- Weight
- Average: 539.58
Monoisotopic: 539.114455133 - Chemical Formula
- C21H25N5O8S2
- InChI Key
- SRXKIZXIRHMPFW-UHFFFAOYSA-N
- InChI
- InChI=1S/C19H17N5O2.2CH4O3S/c20-17(21)14-2-1-13-10-16(8-5-12(13)9-14)26-18(25)11-3-6-15(7-4-11)24-19(22)23;2*1-5(2,3)4/h1-10H,(H3,20,21)(H4,22,23,24);2*1H3,(H,2,3,4)
- IUPAC Name
- 6-carbamimidoylnaphthalen-2-yl 4-carbamimidamidobenzoate; bis(methanesulfonic acid)
- SMILES
- CS(O)(=O)=O.CS(O)(=O)=O.NC(=N)NC1=CC=C(C=C1)C(=O)OC1=CC2=C(C=C1)C=C(C=C2)C(N)=N
- External Links
- KEGG Drug
- D01670
- ChemSpider
- 49623
- ChEBI
- 31890
- ChEMBL
- CHEMBL3989553
- Predicted Properties
Property Value Source Water Solubility 0.0341 mg/mL ALOGPS logP 1.91 ALOGPS logP 2.52 Chemaxon logS -4 ALOGPS pKa (Strongest Basic) 11.32 Chemaxon Physiological Charge 2 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 5 Chemaxon Polar Surface Area 138.07 Å2 Chemaxon Rotatable Bond Count 5 Chemaxon Refractivity 122.12 m3·mol-1 Chemaxon Polarizability 36.46 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon