Triprolidine hydrochloride monohydrateProduct ingredient for Triprolidine
- Name
- Triprolidine hydrochloride monohydrate
- Drug Entry
- Triprolidine
First generation histamine H1 antagonist used in allergic rhinitis; asthma; and urticaria. It is a component of cough and cold medicines. It may cause drowsiness.
- Accession Number
- DBSALT002442
- Structure
Structure for Triprolidine hydrochloride monohydrate (DBSALT002442)
- Synonyms
- Triprolidine hydrochloride / Triprolidine hydrochloride hydrate / Triprolidine hydrochloride monohydrochloride monohydrate
- UNII
- YAN7R5L890
- CAS Number
- 6138-79-0
- Weight
- Average: 332.87
Monoisotopic: 332.1655411 - Chemical Formula
- C19H25ClN2O
- InChI Key
- CUZMOIXUFHOLLN-UMVVUDSKSA-N
- InChI
- InChI=1S/C19H22N2.ClH.H2O/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21;;/h2-3,6-12H,4-5,13-15H2,1H3;1H;1H2/b18-11+;;
- IUPAC Name
- 2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine hydrate hydrochloride
- SMILES
- O.Cl.[H]\C(CN1CCCC1)=C(\C1=CC=C(C)C=C1)C1=CC=CC=N1
- External Links
- KEGG Drug
- D01782
- ChemSpider
- 4445596
- ChEBI
- 32265
- ChEMBL
- CHEMBL3188034
- Predicted Properties
Property Value Source Water Solubility 0.0537 mg/mL ALOGPS logP 4.14 ALOGPS logP 4.05 Chemaxon logS -3.7 ALOGPS pKa (Strongest Basic) 8.64 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 16.13 Å2 Chemaxon Rotatable Bond Count 4 Chemaxon Refractivity 98.53 m3·mol-1 Chemaxon Polarizability 32.63 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule No Chemaxon