Thonzonium bromideProduct ingredient for Thonzonium
- Name
- Thonzonium bromide
- Drug Entry
- Thonzonium
Thonzonium is a monocationic surface-active agent with surfactant and detergent properties. It is widely used as an additive to in ear and nasal drops to enhance dispersion and penetration of cellular debris and exudate, thereby promoting tissue contact of the administered medication. A common pharmaceutical formulation of thonzonium bromide is cortisporin-TC ear drops. It is also reported that thonzonium also confers an antifungal property and antiresorptive effect on bone.
- Accession Number
- DBSALT002554
- Structure
Structure for Thonzonium bromide (DBSALT002554)
- Synonyms
- Tonzonium bromide
- UNII
- JI2B19CR0R
- CAS Number
- 553-08-2
- Weight
- Average: 591.723
Monoisotopic: 590.355925 - Chemical Formula
- C32H55BrN4O
- InChI Key
- WBWDWFZTSDZAIG-UHFFFAOYSA-M
- InChI
- InChI=1S/C32H55N4O.BrH/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-27-36(2,3)28-26-35(32-33-24-19-25-34-32)29-30-20-22-31(37-4)23-21-30;/h19-25H,5-18,26-29H2,1-4H3;1H/q+1;/p-1
- IUPAC Name
- hexadecyl(2-{[(4-methoxyphenyl)methyl](pyrimidin-2-yl)amino}ethyl)dimethylazanium bromide
- SMILES
- [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)CCN(CC1=CC=C(OC)C=C1)C1=NC=CC=N1
- External Links
- ChemSpider
- 10631
- ChEMBL
- CHEMBL1200883
- Wikipedia
- Thonzonium_bromide
- Predicted Properties
Property Value Source Water Solubility 2.13e-05 mg/mL ALOGPS logP 3.53 ALOGPS logP 4.92 Chemaxon logS -7.4 ALOGPS pKa (Strongest Basic) 3.12 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 38.25 Å2 Chemaxon Rotatable Bond Count 22 Chemaxon Refractivity 171.19 m3·mol-1 Chemaxon Polarizability 66.03 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon