Fenspiride hydrochlorideProduct ingredient for Fenspiride

Name
Fenspiride hydrochloride
Drug Entry
Fenspiride

Fenspiride is an oxazolidinone spiro compound used as a drug in the treatment of certain respiratory diseases. It is approved for use in Russia for the treatment of acute and chronic inflammatory diseases of ENT organs and the respiratory tract (like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis), as well as for maintenance treatment of asthma.

Accession Number
DBSALT002867
Structure
Synonyms
Fenspiride HCl / Fenspiride hydrochloride
External IDs
JP 428 / NAT-333 / NDR-5998A
UNII
832NBX878V
CAS Number
5053-08-7
Weight
Average: 296.8
Monoisotopic: 296.1291556
Chemical Formula
C15H21ClN2O2
InChI Key
FIKFLLIUPUVONI-UHFFFAOYSA-N
InChI
InChI=1S/C15H20N2O2.ClH/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13;/h1-5H,6-12H2,(H,16,18);1H
IUPAC Name
8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride
SMILES
Cl.O=C1NCC2(CCN(CCC3=CC=CC=C3)CC2)O1
ChemSpider
61885
ChEMBL
CHEMBL1256849
Predicted Properties
PropertyValueSource
Water Solubility2.75 mg/mLALOGPS
logP1.42ALOGPS
logP1.6Chemaxon
logS-2ALOGPS
pKa (Strongest Acidic)13.29Chemaxon
pKa (Strongest Basic)8.97Chemaxon
Physiological Charge1Chemaxon
Hydrogen Acceptor Count2Chemaxon
Hydrogen Donor Count1Chemaxon
Polar Surface Area41.57 Å2Chemaxon
Rotatable Bond Count3Chemaxon
Refractivity73.73 m3·mol-1Chemaxon
Polarizability29.14 Å3Chemaxon
Number of Rings3Chemaxon
Bioavailability1Chemaxon
Rule of FiveYesChemaxon
Ghose FilterYesChemaxon
Veber's RuleNoChemaxon
MDDR-like RuleNoChemaxon