Lefamulin acetateProduct ingredient for Lefamulin

Lefamulin is a pleuromutilin antibiotic used for the treatment of bacterial community-acquired pneumonia. A pleuromotilin is a more recently developed type of antibiotic that is derived from the fungus, Pleurotus mutilus.⁶ Lefamulin is available in intravenous and oral preparations and was granted FDA approval in August 2019.¹¹ This drug is the first semi-synthetic pleuromutilin that has been designed for systemic administration. Lefamulin features a novel mechanism of action that shows benefit against resistant bacteria that cause pneumonia.¹ The chemical structure of lefamulin contains a tricyclic mutilin core that is necessary for some of its antimicrobial activity.³