Tazemetostat hydrobromideProduct ingredient for Tazemetostat
- Name
- Tazemetostat hydrobromide
- Drug Entry
- Tazemetostat
Tazemetostat is a methyltransferase inhibitor used to treat metastatic or locally advanced epithelioid sarcoma not eligible for complete resection.6 Tazemetostat was first named in literature as EPZ-6438.5
Tazemetaostat was granted FDA approval on 23 January 2020.6
- Accession Number
- DBSALT002932
- Structure
Structure for Tazemetostat hydrobromide (DBSALT002932)
- Synonyms
- Tazemetostat hydrobromide / Tazemetostat monohydrobromide
- External IDs
- EZ-438 / EZ438
- UNII
- 6P89T5M073
- CAS Number
- 1467052-75-0
- Weight
- Average: 653.662
Monoisotopic: 652.262419 - Chemical Formula
- C34H45BrN4O4
- InChI Key
- UQRICAQPWZSJNF-UHFFFAOYSA-N
- InChI
- InChI=1S/C34H44N4O4.BrH/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40;/h6-9,18-20,29H,5,10-17,21-22H2,1-4H3,(H,35,39)(H,36,40);1H
- IUPAC Name
- N-[(4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl]-5-[ethyl(oxan-4-yl)amino]-4-methyl-4'-[(morpholin-4-yl)methyl]-[1,1'-biphenyl]-3-carboxamide hydrobromide
- SMILES
- Br.CCN(C1CCOCC1)C1=C(C)C(=CC(=C1)C1=CC=C(CN2CCOCC2)C=C1)C(=O)NCC1=C(C)C=C(C)NC1=O
- External Links
- ChemSpider
- 34986516
- Predicted Properties
Property Value Source Water Solubility 0.00932 mg/mL ALOGPS logP 4.44 ALOGPS logP 3.45 Chemaxon logS -4.8 ALOGPS pKa (Strongest Acidic) 11.64 Chemaxon pKa (Strongest Basic) 7.19 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 6 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 83.14 Å2 Chemaxon Rotatable Bond Count 9 Chemaxon Refractivity 171.5 m3·mol-1 Chemaxon Polarizability 66.04 Å3 Chemaxon Number of Rings 5 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon