Eprosartan mesylate dihydrateProduct ingredient for Eprosartan
- Name
- Eprosartan mesylate dihydrate
- Drug Entry
- Eprosartan
Eprosartan is an angiotensin II receptor antagonist used to treat hypertension. It performs 2 actions on the renin angiotensin system. By preventing the binding of angiotensin II to AT1, vascular smooth muscle relaxes and vasodilation occurs. By inhibiting norepinephrine production, blood pressure is further reduced.
- Accession Number
- DBSALT002994
- Structure
Structure for Eprosartan mesylate dihydrate (DBSALT002994)
- Synonyms
- Not Available
- UNII
- 9G2HB74868
- CAS Number
- 197855-71-3
- Weight
- Average: 556.65
Monoisotopic: 556.154922966 - Chemical Formula
- C24H32N2O9S2
- InChI Key
- HIUNDVRJXJGSGV-KMDBKMSFSA-N
- InChI
- InChI=1S/C23H24N2O4S.CH4O3S.2H2O/c1-2-3-6-21-24-14-19(12-18(23(28)29)13-20-5-4-11-30-20)25(21)15-16-7-9-17(10-8-16)22(26)27;1-5(2,3)4;;/h4-5,7-12,14H,2-3,6,13,15H2,1H3,(H,26,27)(H,28,29);1H3,(H,2,3,4);2*1H2/b18-12+;;;
- IUPAC Name
- 4-({2-butyl-5-[(1E)-2-carboxy-2-[(thiophen-2-yl)methyl]eth-1-en-1-yl]-1H-imidazol-1-yl}methyl)benzoic acid methanesulfonic acid dihydrate
- SMILES
- O.O.CS(O)(=O)=O.[H]\C(=C(\CC1=CC=CS1)C(O)=O)C1=CN=C(CCCC)N1CC1=CC=C(C=C1)C(O)=O
- External Links
- ChemSpider
- 8048128
- Predicted Properties
Property Value Source Water Solubility 0.00866 mg/mL ALOGPS logP 3.57 ALOGPS logP 3.75 Chemaxon logS -4.7 ALOGPS pKa (Strongest Acidic) 3.47 Chemaxon pKa (Strongest Basic) 6.67 Chemaxon Physiological Charge -2 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 2 Chemaxon Polar Surface Area 92.42 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 117.02 m3·mol-1 Chemaxon Polarizability 45.22 Å3 Chemaxon Number of Rings 3 Chemaxon Bioavailability 1 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon