Carbocisteine lysineProduct ingredient for Carbocisteine
- Name
- Carbocisteine lysine
- Drug Entry
- Carbocisteine
Dyspnea and cough are common symptoms of chronic obstructive pulmonary disease (COPD)11 and other respiratory conditions characterized by increased mucus production. Individuals with COPD have a greater risk of pulmonary infection due to the growth and accumulation of viruses and bacteria in thick bronchial mucus. Carbocisteine is a mucolytic drug that alleviates respiratory symptoms and infections by reducing the viscosity of mucus, allowing it to be expelled.16
Several licenses for this drug were withdrawn following serious and fatal paradoxical effects after carbocisteine therapy in children; respiratory dress, dyspnea, and cough aggravation were reported by physicians in France and Italy.3 Carbocisteine is currently not FDA or Health Canada approved, but is approved for use in Asia, Europe, and South America.
- Accession Number
- DBSALT003064
- Structure
Structure for Carbocisteine lysine (DBSALT003064)
- Synonyms
- Carbocysteine lysine / Lysine carbocysteinate / Lysine carboxymethyl cysteinate
- External IDs
- 256-425-9
- UNII
- 1D1Y95PXXA
- CAS Number
- 49673-81-6
- Weight
- Average: 325.38
Monoisotopic: 325.130756647 - Chemical Formula
- C11H23N3O6S
- InChI Key
- SAGXGPWVLUSDSQ-RVZXSAGBSA-N
- InChI
- InChI=1S/C6H14N2O2.C5H9NO4S/c7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-11-2-4(7)8/h5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10)/t5-;3-/m00/s1
- IUPAC Name
- (2R)-2-amino-3-[(carboxymethyl)sulfanyl]propanoic acid; (2S)-2,6-diaminohexanoic acid
- SMILES
- NCCCC[C@H](N)C(O)=O.N[C@@H](CSCC(O)=O)C(O)=O
- External Links
- ChemSpider
- 4954595
- Predicted Properties
Property Value Source Water Solubility 21.6 mg/mL ALOGPS logP -3.2 ALOGPS logP -3.3 Chemaxon logS -0.92 ALOGPS pKa (Strongest Acidic) 1.84 Chemaxon pKa (Strongest Basic) 9.14 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 5 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 100.62 Å2 Chemaxon Rotatable Bond Count 10 Chemaxon Refractivity 39.11 m3·mol-1 Chemaxon Polarizability 16.72 Å3 Chemaxon Number of Rings 0 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon