Umbralisib tosylateProduct ingredient for Umbralisib
- Name
- Umbralisib tosylate
- Drug Entry
- Umbralisib
Marginal zone lymphoma is a rare, slowly progressing type of non-Hodgkin lymphoma initially treated with rituximab (an anti-CD20 drug), either alone or in combination with chemotherapy. Unfortunately, many patients experience a relapse or develop resistance to these drugs. Treatment options then become limited, and alternate treatments for the lymphoma are required to control disease progression.1 Follicular lymphoma is also treated with rituximab and other chemotherapeutic agents, but may show similar progression.5
On February 5, 2021, the Food and Drug Administration granted accelerated approval to umbralisib, a kinase inhibitor for PI3K-delta and casein kinase CK1-epsilon, based on promising results from clinical trials. It was marketed as Ukoniq by TG Therapeutics and has been approved for the treatment of relapsing and refractory marginal cell lymphoma and follicular lymphoma in adults.6 Umbralisib inhibits casein kinase, a primary regulator of protein translation, kinase-1ε, distinguishing it from other lymphoma treatments. While it initially offered a promising therapy for patients experiencing relapsing or refractory disease,1 umbralisib was withdrawn from the market due to safety concerns as the drug was associated with a possible increased risk of death outweighing the benefits.10
- Accession Number
- DBSALT003156
- Structure
- Synonyms
- Umbralisib tosylate
- External IDs
- RP-5307
- UNII
- FU8XW5V3FS
- CAS Number
- 1532533-72-4
- Weight
- Average: 743.76
Monoisotopic: 743.202539433 - Chemical Formula
- C38H32F3N5O6S
- InChI Key
- KYJWUPZPSXZEPG-NTISSMGPSA-N
- InChI
- InChI=1S/C31H24F3N5O3.C7H8O3S/c1-15(2)41-24-9-7-18(12-22(24)34)27-26-30(35)36-14-37-31(26)39(38-27)16(3)29-25(17-5-4-6-19(32)11-17)28(40)21-13-20(33)8-10-23(21)42-29;1-6-2-4-7(5-3-6)11(8,9)10/h4-16H,1-3H3,(H2,35,36,37);2-5H,1H3,(H,8,9,10)/t16-;/m0./s1
- IUPAC Name
- 2-[(1S)-1-{4-amino-3-[3-fluoro-4-(propan-2-yloxy)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}ethyl]-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one; 4-methylbenzene-1-sulfonic acid
- SMILES
- CC1=CC=C(C=C1)S(O)(=O)=O.[H][C@@](C)(N1N=C(C2=C1N=CN=C2N)C1=CC=C(OC(C)C)C(F)=C1)C1=C(C2=CC=CC(F)=C2)C(=O)C2=C(O1)C=CC(F)=C2
- External Links
- ChemSpider
- 58790036
- ChEMBL
- CHEMBL3989869
- Predicted Properties
Property Value Source logP 6.13 Chemaxon pKa (Strongest Acidic) 19.68 Chemaxon pKa (Strongest Basic) 4.01 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 7 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 105.15 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 163.22 m3·mol-1 Chemaxon Polarizability 56.31 Å3 Chemaxon Number of Rings 7 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon