Donepezil hydrochloride monohydrateProduct ingredient for Donepezil
- Name
- Donepezil hydrochloride monohydrate
- Drug Entry
- Donepezil
In 2016, the global burden of dementia was estimated to be 43.8 million, demonstrating a significant increase from a global prevalence of 20.2 million in 1990.16 Donepezil, also known as Aricept, is a piperidine derivative acetylcholinesterase inhibitor used in the management of the dementia of Alzheimer's Disease, and in some cases, is used to manage other types of dementia.
Donepezil was first approved by the FDA in 1996, and its extended-release form was approved in combination with Memantine in 2014 to manage moderate and severe forms of Alzheimer's dementia.19,22 A donepezil transdermal delivery system, Adlarity, was approved by the FDA in March 2022 for the treatment of Alzheimer's dementia.24 Though it does not alter the progression of Alzheimer's disease, donepezil is effective in managing the symptoms of its associated dementia.18
- Accession Number
- DBSALT003199
- Structure
Structure for Donepezil hydrochloride monohydrate (DBSALT003199)
- Synonyms
- Donepezil HCl monohydrate
- UNII
- 7KZL5YRL6W
- CAS Number
- 884740-09-4
- Weight
- Average: 433.97
Monoisotopic: 433.2019862 - Chemical Formula
- C24H32ClNO4
- InChI Key
- HLJIZAKUNCTCQX-UHFFFAOYSA-N
- InChI
- InChI=1S/C24H29NO3.ClH.H2O/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H;1H2
- IUPAC Name
- 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one hydrate hydrochloride
- SMILES
- O.Cl.COC1=CC2=C(C=C1OC)C(=O)C(CC1CCN(CC3=CC=CC=C3)CC1)C2
- External Links
- ChemSpider
- 9872489
- ChEMBL
- CHEMBL2337271
- Predicted Properties
Property Value Source Water Solubility 0.0045 mg/mL ALOGPS logP 4.14 ALOGPS logP 4.21 Chemaxon logS -4.9 ALOGPS pKa (Strongest Acidic) 16.78 Chemaxon pKa (Strongest Basic) 9.12 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 38.77 Å2 Chemaxon Rotatable Bond Count 6 Chemaxon Refractivity 112.11 m3·mol-1 Chemaxon Polarizability 44.27 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule Yes Chemaxon MDDR-like Rule Yes Chemaxon