Telmisartan sodiumProduct ingredient for Telmisartan
- Name
- Telmisartan sodium
- Drug Entry
- Telmisartan
Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascular smooth muscle, ultimately leading to a reduction in arterial blood pressure.1,2 Recent studies suggest that telmisartan may also have PPAR-gamma agonistic properties that could potentially confer beneficial metabolic effects.3
- Accession Number
- DBSALT003204
- Structure
Structure for Telmisartan sodium (DBSALT003204)
- Synonyms
- Telmisartan sodium salt
- UNII
- K15TQY55Q7
- CAS Number
- 515815-47-1
- Weight
- Average: 536.611
Monoisotopic: 536.21882047 - Chemical Formula
- C33H29N4NaO2
- InChI Key
- RSGAIWOEJXRYRV-UHFFFAOYSA-M
- InChI
- InChI=1S/C33H30N4O2.Na/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39;/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39);/q;+1/p-1
- IUPAC Name
- sodium 4'-{[4-methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}-[1,1'-biphenyl]-2-carboxylate
- SMILES
- [Na+].CCCC1=NC2=C(C=C(C=C2C)C2=NC3=C(C=CC=C3)N2C)N1CC1=CC=C(C=C1)C1=C(C=CC=C1)C([O-])=O
- External Links
- ChemSpider
- 8295026
- Predicted Properties
Property Value Source Water Solubility 0.00316 mg/mL ALOGPS logP 6.85 ALOGPS logP 6.13 Chemaxon logS -5.2 ALOGPS pKa (Strongest Acidic) 3.62 Chemaxon pKa (Strongest Basic) 5.86 Chemaxon Physiological Charge -1 Chemaxon Hydrogen Acceptor Count 4 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 75.77 Å2 Chemaxon Rotatable Bond Count 7 Chemaxon Refractivity 175.33 m3·mol-1 Chemaxon Polarizability 58.54 Å3 Chemaxon Number of Rings 6 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like Rule Yes Chemaxon