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Displaying results 91 - 100 of 178313 in total
  1. Drug

    GTP-506

    go.drugbank.com/drugs/DB17682
    Experimental

    GTP-506 is a gene therapy formed by two vectors, a nuclease vector targeting gene editing in the well-characterized PCSK9 gene locus and a therapeutic donor vector that inserts the OTC gene to provide

    Synonyms: Non-replicating recombinant adeno-associated virus serotype rh79 (AAVrh.79) vectors: AAVrh79.TBG.M2PCSK9.WPRE.bGH and AAVrh79.hHDR.TBG.hOTCco.bGH
  2. Drug

    TPX-4589

    go.drugbank.com/drugs/DB18604
    Investigational

    TPX-4589 is an antibody-drug conjugate composed of a humanized monoclonal antibody targeting CLDN18.2 and linker-payload MC-VC-PAB-MMAE.

    Synonyms: Antibody drug conjugate composed of a humanized monoclonal antibody targeting CLDN18.2 and linker-payload MC-VC-PAB-MMAE
  3. Drug

    VOR33

    go.drugbank.com/drugs/DB18624
    Investigational

    VOR33 is an allogeneic CRISPR/Cas9 genome-edited hematopoietic stem and progenitor cell (HSPC) therapy product lacking the CD33 protein.

    Synonyms: allogeneic CRISPR/Cas9 genome-edited hematopoietic stem and progenitor cell (HSPC) therapy product lacking the CD33 protein
  4. Drug

    Nipocalimab

    go.drugbank.com/drugs/DB16257
    ApprovedInvestigational

    [L64042] It is an aglycosylated, fully human IgG1 monoclonal antibody that binds FcRn and blocks the receptor's recycling of immunoglobulin G (IgG), thereby lowering circulating IgG levels, including pathogenic … Nipocalimab-aahu is a neonatal Fc receptor (FcRn) blocker used to treat certain antibody-mediated autoimmune diseases.

    Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsSynonyms: immunoglobulin G1-lambda, anti-[Homo sapiens FCGRT (Fc fragment of IgG receptor and transporter, neonatal Fc receptor, FcRn, transmembrane alpha chain of the neonatal receptor)], Homo sapiens monoclonal, antibody (gamma1 heavy chain Homo sapiens (1-445)
  5. Drug

    Magnolia kobus bark

    go.drugbank.com/drugs/DB14563
    Investigational

    Synonyms: Buergeria obovata bark, Magnolia kobus bark
  6. Drug

    Spanlecortemlocel

    go.drugbank.com/drugs/DB17130
    Investigational

    Synonyms: ALLOGENEIC UMBILICAL CORD BLOOD-DERIVED HEMATOPOIETIC STEM AND PROGENITOR CELLS MGTA-456, Allogeneic umbilical cord blood (UCB) cell therapy product consisting of two cell fractions (CD34 enriched and CD34 depleted) derived from the same UCB unit
  7. Drug

    Phellodendron amurense bark

    go.drugbank.com/drugs/DB14370
    Investigational

    Phellodendron amurense bark is a plant/plant extract used in some OTC (over-the-counter) products. It is not an approved drug.

    Synonyms: Amur Cork Tree Bark, Phellodendron amurense barkProducts: Jayeonbi Secret Care Mist for Lady Y-zone Mist, Jayeonbi Secret Care Mist for Men Y-zone Mist
  8. Drug

    CVac

    go.drugbank.com/drugs/DB17351
    Experimental

    Synonyms: Autologous dendritic cells pulsed with recombinant human fusion protein (MUCIN1 and Glutathione S Transferase) coupled to oxidized polymannose
  9. Drug

    NTLA-2002

    go.drugbank.com/drugs/DB17597
    Investigational

    NTLA-2002 is a lipid nanoparticle encapsulating single guide RNA (G012267) targeting the human KLKB1 gene and messenger RNA (mRNA000042) encoding Cas9. … It is an investigational therapy designed to knock out the target gene kallikrein B1 (KLKB1) to reduce plasma kallikrein activity, thereby preventing hereditary angioedema attacks.[L45738]

    Synonyms: lipid nanoparticle encapsulating single guide RNA (G012267) targeting the human KLKB1 gene and messenger RNA (mRNA000042) encoding Cas9
  10. Drug

    Veverimer

    go.drugbank.com/drugs/DB18977
    Investigational

    Veverimer is under investigation in clinical trial NCT03390842 (Long-term Safety Extension to Study TRCA-301).

    Synonyms: 1,3-propanediamine, n1,n3-di-2-propen-1-yl-, polymer with 1,2-dichloroethane and 2-propen-1-amine, N1,n3-bis(prop-2-en-1-yl)propan-1,3-diamine copolymer with 1,2-dichloroethane and prop-2-en-1-amine