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Displaying results 1021 - 1030 of 1186 in total
  1. Target

    Serotonin Receptors

    go.drugbank.com/bio_entities/BE0004862
    TargetHumans

    Receptor for lasmiditan, a drug for the treatment of acute migraine (PubMed:34239069). … G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731).

    Polypeptides: 5-hydroxytryptamine receptor 1A, 5-hydroxytryptamine receptor 1BSynonyms: Serotonin receptor 1A, Serotonin receptor 1B
  2. Drug

    Cholecystokinin

    go.drugbank.com/drugs/DB08862
    ApprovedInvestigationalWithdrawn

    Recent studies have suggested that cholecystokinin also plays a major role in inducing drug tolerance to opioids such as morphine and heroin, and is partially implicated in experiences of pain hypersensitivity

  3. Drug

    Omburtamab

    go.drugbank.com/drugs/DB15635
    Investigational

    CD276 (B7-H3) is a B7/CD28 immunoglobulin superfamily member frequently expressed among solid human tumours. Omburtamab, formerly the murine anti-B7-H3 antibody 8H9, and its humanized forms are currently under clinical development for us...

  4. Target

    Alpha-1 adrenergic receptors

    go.drugbank.com/bio_entities/BE0004863
    TargetHumans

    Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenge...

    Polypeptides: Alpha-1A adrenergic receptor, Alpha-1B adrenergic receptorSynonyms: Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c
  5. Target

    Alpha-2 adrenergic receptors

    go.drugbank.com/bio_entities/BE0004864
    TargetHumans

    Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (...

    Polypeptides: Alpha-2A adrenergic receptor, Alpha-2B adrenergic receptorSynonyms: Alpha-2 adrenergic receptor subtype C10, Alpha-2 adrenergic receptor subtype C2
  6. Drug

    Tramadol

    go.drugbank.com/drugs/DB00193
    ApprovedInvestigational

    property through different mechanisms and are also themselves metabolized into active metabolites: (+)-tramadol and its primary metabolite (+)-O-desmethyl-tramadol (M1) are agonists of the μ opioid receptor

    Mixtures: Skudexa 75 mg/25 mg Granulat im Beutel zur Herstellung einer Lösung zum EinnehmenCategories: NMDA Receptor Antagonists, Serotonin Receptor Antagonists
  7. Drug

    Ioxaglic acid

    go.drugbank.com/drugs/DB09313
    ApprovedWithdrawn

    Ioxaglic acid is marketed as Hexabrix. This drug is an ionic tri-iodinated benzoate used as a low-osmolality contrast agent during diagnostic imaging procedures. Like other organic iodine compounds, ioxaglic acid blocks x-rays and is opa...

  8. Drug

    Alprazolam

    go.drugbank.com/drugs/DB00404
    ApprovedIllicitInvestigational

    Alprazolam is a triazolobenzodiazepine indicated for the treatment of anxiety and panic disorders. It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole. Benzodiazepine trea...

  9. Drug

    Paramethasone

    go.drugbank.com/drugs/DB01384
    Experimental

    A glucocorticoid with the general properties of corticosteroids. It has been used by mouth in the treatment of all conditions in which corticosteroid therapy is indicated except adrenal-deficiency states for which its lack of sodium-reta...

  10. Target

    Eph receptors

    go.drugbank.com/bio_entities/BE0028186
    TargetHumans

    Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5 … Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3.

    Polypeptides: Ephrin type-A receptor 1, Ephrin type-A receptor 10Synonyms: Tyrosine-protein kinase receptor EPH, Tyrosine-protein kinase receptor ECK