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Desogestrel

[A176342] The first approved drug containing desogestrel was developed by Organon USA Inc in 1972 and FDA approved in 1992.[L5762]

Piperonyl butoxide

It has no pesticidal activity of its own, but acts to increase the activity of pesticides such as carbamates, pyrethrins, pyrethroids, and rotenone.

Dronedarone

[A34604,L8699] Dronedarone is a related benzofuran compound to amiodarone but its chemical structure lacks iodine moieties which are associated with amiodarone-induced thyroid problems. … It is managed by rate control, rhythm control, prevention of thromboembolic events, and treatment of the underlying disease.

Gadodiamide

[A263096] Approved by the FDA in 1993, gadodiamide is the first non-ionic GBCA to be used.

Ancestim

[T68] It was also approved by Health Canada in 1999 but it is currently under the status of canceled post-market.[L1087] … Ancestim was developed by Amgen and sold to Biovitrium in December 2008. It was submitted to the FDA under the status of recommendation for approval with a 10 to 1 votes.

Dantrolene

Chemically, dantrolene is a hydantoin derivative, but does not exhibit antiepileptic activity like other hydantoin derivates such as phenytoin.

Sacubitril

It was approved by the FDA after being given the status of priority review for on July 7, 2015.

Ustekinumab

In October 2019, it was also approved by the FDA for use to manage moderately to severely active ulcerative colitis in adults.

Milbemycin oxime

Elvitegravir

Elvitegravir was first licensed from Japan Tobacco in 2008 and developed by Gilead Sciences. It was FDA approved on August 27, 2012.