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Gliclazide
go.drugbank.com/drugs/DB01120ApprovedInvestigationalGliclazide is an oral antihyperglycemic agent used for the treatment of non-insulin-dependent diabetes mellitus (NIDDM). … Gliclazide is extensively metabolized by the liver; its metabolites are excreted in both urine (60-70%) and feces (10-20%).
Categories: Drugs Used in Diabetes, Cytochrome P-450 SubstratesSynonyms: 1-(3-azabicyclo(3.3.0)oct-3-yl)-3-(p-tolylsulfonyl)urea, 1-(hexahydrocyclopenta(c)pyrrol-2(1H)-yl)-3-(p-tolylsulfonyl)ureaUrethane
go.drugbank.com/drugs/DB04827ApprovedWithdrawnUrethane, formerly marketed as an inactive ingredient in Profenil injection, was determined to be carcinogenic and was removed from the Canadian, US, and UK markets in 1963.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 SubstratesAtaluren
go.drugbank.com/drugs/DB05016ApprovedWithdrawnThis drug does not yet have approval by the US Food and Drug Administration or by Health Canada for any indications. … Ataluren is approved for use by the European Medicines Agency to treat Duchenne Muscular Dystrophy in patients aged 5 years and older who are able to walk.
Categories: Heterocyclic Compounds, 1-RingSynonyms: 3-[5-(2-fluorophenyl)-1,2,4-oxadiazol-3-yl]benzoic acidDepemokimab
go.drugbank.com/drugs/DB18846ApprovedInvestigational[A275338] Approved by the FDA on December 16, 2025, depemokimab is indicated as an add-on maintenance treatment for severe asthma characterized by an eosinophilic phenotype in adult and paediatric patients … [A275338, L54758] Its long duration of action is granted by seven amino acid substitutions in the heavy chain sequence.
Categories: Interleukin-5 AntagonistSynonyms: Immunoglobulin g1, anti-(human interleukin 5) (human-mus musculus monoclonal gsk3511294 .gamma.1-chain), disulfide with human-mus musculus monoclonal gsk3511294 .kappa.-chain, dimerBrexucabtagene autoleucel
go.drugbank.com/drugs/DB15699ApprovedInvestigationalMantle cell lymphoma (MCL) is a heterogeneous sub-category of non-Hodgkin's lymphoma that can be classified as either an aggressive nodal or an indolent leukemic non-nodal variant. … tumour cells in the CAR T cell preparation.
Categories: Receptors, Antigen, T-Cell, CD19-Directed Genetically Modified Autologous T-cell ImmunotherapiesLevallorphan
go.drugbank.com/drugs/DB00504ApprovedIt should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants … An opioid antagonist with properties similar to those of naloxone; in addition it also possesses some agonist properties.
Categories: Heterocyclic Compounds with 4 or More RingsEbola Zaire vaccine (live, attenuated)
go.drugbank.com/drugs/DB15595ApprovedInvestigational[L10854] Ebola virus disease, formerly known as Ebola hemorrhagic fever, is a rare but severe and often deadly disease. … [L10866] In non-human primate clinical trials, the vaccine was effective in inducing an immune response against the Ebola viruses.
Synonyms: Ebola Zaire Vaccine (rVSV∆G-ZEBOV-GP, live), EBOLA ZAÏRE VACCINE (rVSV [DELTA] G-ZEBOV-GP, LIVE)Prenylamine
go.drugbank.com/drugs/DB04825ApprovedWithdrawnPrenylamine was withdrawn from the Canadian, US, and UK markets in 1988 due to concerns regarding cardiac arrhythmias.
Categories: Vasodilators Used in Cardiac Diseases, Cytochrome P-450 SubstratesSynonyms: N-(1-Methyl-2-phenylethyl)-gamma-phenylbenzenepropanamine, N-(3,3-Diphenylpropyl)-alpha-methylphenaethylaminZomepirac
go.drugbank.com/drugs/DB04828ApprovedWithdrawnThe manufacturer voluntarily removed Zomax tablets from the Canadian, US, and UK markets in March 1983.
Categories: Non COX-2 selective NSAIDS, Analgesics, Non-NarcoticSynonyms: 5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetic acidNADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
go.drugbank.com/bio_entities/BE0000305TargetHumansRequired for proper complex I assembly (PubMed:28671271). Complex I functions in the transfer of electrons from NADH to the respiratory chain. … Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.
Synonyms: Complex I-39kD